Reference

Preparation of isotopically substituted benzimidazoles as proton pump inhibitors

All Rights Reserved. Several substances are used for example 922727-41-1 and 368890-20-4 which are their cas registry numbers. Preparation of isotopically substituted benzimidazoles as proton pump inhibitors. Kohl, Bernhard; Mueller, Bernd; Haag, Dieter; Simon, Wolfgang-Alexander; Zech, Karl; David, Michael; Von Richter, Oliver; Huth, Felix (Altana Pharma A.-G., Germany). PCT Int. Appl. WO 2007012650 A1 1 Feb 2007, 55pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IS, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. APPLICATION: WO 2006-EP64666 26 Jul 2006. PRIORITY: EP 2005-106868 26 Jul 2005. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 63 Title compds. represented by the formula I [wherein R1 = H or alkoxy; R2 = alkyl or alkoxy; R3 = alkyl or (alkoxy)alkoxy; R4 = H or alkyl; Z = CH or N; n = 0 or 1; at least one of the hydrogen atoms of R1-R4 or any combination of R1-R4 is replaced by a deuterium atom; and their salts, solvates hydrates thereof] were prepd. as proton pump inhibitors. For example, II (n = 1) was provided in 95% yield by oxidn. of II (n = 0) with sodium hypochlorite. I were tested for metabolization in liver microsomes and formation kinetics of pantoprazole M2. Thus, I and their pharmaceutical compns. are useful for the treatment and/or prophylaxis of gastrointestinal disorders. .