Detail of "3691-35-8"

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High-performance liquid chromatographic strategies for the determination and confirmation of anticoagulant rodenticide residues in animal tissues

High-performance liquid chromatographic strategies for the determination and confirmation of anticoagulant rodenticide residues in animal tissues. Hunter, K. (Agric. Sci. Serv., Dep. Agric. Fish. Scotland, East Craigs/Edinburgh EH12 8NJ, UK). J. Chromatogr., 321(2), 255-72 (English) 1985. CODEN: JOCRAM. ISSN: 0021-9673. DOCUMENT TYPE: Journal CA Section: 5 (Agrochemical Bioregulators) Section cross-reference(s): 4, 80 Residues of warfarin [81-81-2], coumatetralyl [5836-29-3], difenacoum [56073-07-5], brodifacoum [56073-10-0], bromadiolone [28772-56-7], diphacinone [82-66-6], and chlorophacinone [3691-35-8] in animal tissues were extd. with CHCl3-MeCO (1:1, vol./vol.). Exts. were cleaned-up by an integrated gel permeation and adsorption chromatog. procedure which divided the rodenticides into 2 groups. Residues were then detd. and confirmed using normal-phase, ion-pair and weak ion-exchange HPLC techniques. Ion-pair gradient sepn. resolved all 7 rodenticides in a single chromatog. anal. UV detection methods were employed for all 7 rodenticides. Use of a diode array detection system permitted addnl. confirmation of residues down to 0.1 mg/kg by matching UV spectra and derivs. of spectra. Sensitive fluorescence detection was possible for the coumarin-based rodenticides, but not for diphacinone and chlorophacinone. Post-column pH-switching fluorescence detection methods were superior to other methods of fluorescence detection of coumarin-based rodenticides. Recoveries from spiked liver tissue were around 90% at levels from 0.05 to 1 mg/kg. Detection limits of around 0.002 mg/kg for most rodenticides and of 0.01 mg/kg for warfarin could be achieved with animal tissue exts.

Effect of humic acids on the acute toxicity of selected pesticides

Effect of humic acids on the acute toxicity of selected pesticides. Golbs, Siegfried; Kuehnert, M.; Fuchs, V. (WB Pharmakol., Pharm. Toxikol., Karl-Marx-Univ., Leipzig DDR-7010, Ger. Dem. Rep.). Z. Gesamte Hyg. Ihre Grenzgeb., 30(12), 720-3 (German) 1984. CODEN: ZHYGAM. ISSN: 0049-8610. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Oral administration of parathion-methyl [298-00-0], lindane (I) [58-89-9], chlorophacinone [3691-35-8], or carbaryl [63-25-2] (LD50) with 500 mg humic acids/kg decreases the pesticide toxicities by 76-81, 42-56, 49-80, and 10-19%, resp. Acetylcholinesterase [9000-81-1] activity in blood decreased after chronic administration of 6-12 mg parathion-methyl/kg daily and improved or normalized when the pesticide was administered with 200 mg; changes in blood serum proteins also normalized. Warfarin [81-81-2] (LD50) was detoxified by 500 mg humic acids/kg/day. Mechanisms are discussed of the protective effects of humic acids against pesticide poisoning.