Detail of "37076-68-9"

CAS Number:
37076-68-9
Name:
2,4(1H,3H)-Pyrimidinedione,5-fluoro-1-[(2R)-tetrahydro-2-furanyl]-
Superlist Name:
Tegafur
Molecular Structure:
Formula:
C₈H₉FN₂O₃
Molecular Weight:
200.1671
Synonyms:
2,4(1H,3H)-Pyrimidinedione,5-fluoro-1-(tetrahydro-2-furanyl)-, (R)-;(R)-Ftorafur;NSC 200695;5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;2,4(1H,3H)-pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)-;5-fluoro-1-(tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione;Carzonal;N1-(2'-Furanidyl)-5-fluorouracil;Tegafur;
EINECS:
241-846-2
Density:
1.45 g/cm³
Melting Point:
171-173 °C(lit.)
Hazard Symbols:
T
Risk Codes:
23/24/25
Safety:
22-36/37/39-45 Details
Transport Information:
UN 2811 6.1/PG 2

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Assay:99.0% Min

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CBNumber: CB5419052 Chemical Name: TEGAFUR Molecular Formula: C8H9FN2O3 Formula Weight: 200.17 CAS No.: 37076-68-9 MOL File: Mol file

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Studies of antitumor agents: Studies of antitumor agents. 1. Resolution of racemic 1-(tetrahydro-2-furanyl)-5-fluorouracil into the R and S isomers and examination of the biological activities of the isomers. Yasumoto, Mitsugi; Moriyama, Akira; Unemi, Norio; Hashimoto, Sadao; Suzue, Takashi (Res. Lab., Taiho Pharm. Co., Tokushima, Japan). J. Med. Chem., 20(12), 1592-4 (English) 1977. CODEN: JMCMAR. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 28 Condensation of 2,4-bis(trimethylsilyl)-5-fluorouracil [17242-85-2] with 2-acetoxytetrahydrofuran [1608-67-9] in the presence of NaI gave racemic Ftorafur (I) [17902-23-7], which was resolved via the brucine salts to R-(+)-I [37076-68-9] and S-(-)-I [55774-30-6]. No significant differences were found between the racemic form and the isomers in antibacterial activity, in vivo antitumor activity, or degrdn. to 5-fluorouracil by liver microsomes.