CAS No.371-62-0,2-Fluoroethanol Suppliers

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Basic Information

Molecular Structure:
CAS No.:	371-62-0
Name:	2-Fluoroethanol
Article Data:	32

Formula:	C₂H₅FO
Molecular Weight:	64.0595
Synonyms:	1-Fluoroethan-2-ol;Ethylene fluorohydrin;Flutritex 2;NSC 158283;b-Fluoroethanol;
EINECS:	206-740-2
Density:	0.993 g/cm³
Melting Point:	-26.5 °C(lit.)
Boiling Point:	103.5 °C at 760 mmHg
Flash Point:	31.1 °C
Appearance:	Colorless Liquid
Hazard Symbols:	F; T+
Risk Codes:	10-26/27/28
Safety:	36/37/39-45
Transport Information:	UN 3383 6.1/PG 1
PSA:	20.23000
LogP:	-0.05180

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Consensus Reports

EPA Extremely Hazardous Substances List. Reported in EPA TSCA Inventory.

Specification

The IUPAC name of this chemical is 2-Fluoroethanol. With the CAS registry number 371-62-0 and EINECS registry number 206-740-2, it is also named as ethanol,2-fluoro-. In addition, the molecular formula is C₂H₅FO and the molecular weight is 64.06. It belongs to the classes of Pharmaceutical Intermediates; Alcohols; C2 to C6; Oxygen Compounds. And it should be stored in brown glass bottles, then put in a cool and dry place.

Physical properties about this chemical are: (1)ACD/LogP: -0.47; (2)ACD/LogD (pH 5.5): -0.47; (3)ACD/LogD (pH 7.4): -0.47; (4)ACD/BCF (pH 5.5): 1; (5)ACD/BCF (pH 7.4): 1; (6)ACD/KOC (pH 5.5): 13.22; (7)ACD/KOC (pH 7.4): 13.22; (8)#H bond acceptors: 1; (9)#H bond donors: 1; (10)#Freely Rotating Bonds: 2; (11)Polar Surface Area: 9.23 Å²; (12)Index of Refraction: 1.325; (13)Molar Refractivity: 13.01 cm³; (14)Molar Volume: 64.5 cm³; (15)Polarizability: 5.15 ×10^-24cm³; (16)Surface Tension: 20.9 dyne/cm; (17)Density: 0.993 g/cm³; (18)Flash Point: 31.1 °C; (19)Enthalpy of Vaporization: 39.94 kJ/mol; (20)Boiling Point: 103.5 °C at 760 mmHg; (21)Vapour Pressure: 17.8 mmHg at 25°C.

Preparation of 2-Fluoroethanol: it can be prepared by 2-fluoroethyl fluorosulfite. This reaction will need reagent 15percent KOH and solvent H₂O. The reaction time is 2 hours. The yield is about 90%.

2-Fluoroethanol can be prepared by 2-fluoroethyl fluorosulfite

Uses of 2-Fluoroethanol: it is used as pesticides and medicine intermediates. And it can react with 3,4-dihydro-2H-pyran to get 2-(2'-fluoroethoxy)tetrahydropyran. This reaction will need reagent conc.HCl. The reaction time is 3 hours. The yield is about 52%.

2-Fluoroethanol can react with 3,4-dihydro-2H-pyran to get 2-(2'-fluoroethoxy)tetrahydropyran

When you are using this chemical, please be cautious about it as the following:
This chemical is flammable. And it is very toxic by inhalation, in contact with skin and if swallowed. During using it, wear suitable protective clothing, gloves and eye/face protection. In case of accident or if you feel unwell, seek medical advice immediately (show label where possible).

You can still convert the following datas into molecular structure:
(1)SMILES: FCCO
(2)InChI: InChI=1/C2H5FO/c3-1-2-4/h4H,1-2H2
(3)InChIKey: GGDYAKVUZMZKRV-UHFFFAOYAT

The toxicity data is as follows:

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
cat	LC50	inhalation	35mg/m³/10M (35mg/m³)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
dog	LC50	inhalation	7mg/m³/10M (7mg/m³)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
guinea pig	LC50	inhalation	150mg/m³/10M (150mg/m³)		National Technical Information Service. Vol. PB158-508,
monkey	LC50	inhalation	1500mg/m³/10M (1500mg/m³)	BEHAVIORAL: COMA LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS	National Technical Information Service. Vol. PB158-508,
mouse	LC50	inhalation	1100mg/m³/10M (1100mg/m³)		Journal of the Chemical Society. Vol. -, Pg. 773, 1949.
mouse	LD50	intraperitoneal	10mg/kg (10mg/kg)		Journal of Organic Chemistry. Vol. 21, Pg. 739, 1956.
mouse	LD50	subcutaneous	15mg/kg (15mg/kg)		Nature. Vol. 172, Pg. 1139, 1953.
rabbit	LC50	inhalation	25mg/m³/10M (25mg/m³)	BEHAVIORAL: COMA GASTROINTESTINAL: CHANGES IN STRUCTURE OR FUNCTION OF SALIVARY GLANDS LUNGS, THORAX, OR RESPIRATION: RESPIRATORY STIMULATION	National Technical Information Service. Vol. PB158-508,
rabbit	LDLo	intravenous	250ug/kg (0.25mg/kg)		Journal of the Chemical Society. Vol. -, Pg. 1279, 1949.
rat	LC50	inhalation	200mg/m³/10M (200mg/m³)		National Technical Information Service. Vol. PB158-508,
rat	LD50	intraperitoneal	1750ug/kg (1.75mg/kg)	BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLD	Journal of Pharmacy and Pharmacology. Vol. 20, Pg. 465, 1968.
rat	LD50	oral	5mg/kg (5mg/kg)		"Prehled Prumyslove Toxikologie; Organicke Latky," Marhold, J., Prague, Czechoslovakia, Avicenum, 1986Vol. -, Pg. 515, 1986.