Reference

Influence of adrenergic b2 agonist, 4-amino-a-[(tert-butylamino)methyl]-3,5-dichlorobenzylalcohol hydrochloride (Clenbuterol), on the gastrointestinal function

Influence of adrenergic b2 agonist, 4-amino-a-[(tert-butylamino)methyl]-3,5-dichlorobenzylalcohol hydrochloride (Clenbuterol), on the gastrointestinal function. Watanabe, Kazuo; Watanabe, Hiroshi; Goto, Yoshiaki; Hagiwara, Masaki (Res.Several substances are used for example 72332-33-3 and 51-41-2 which are their cas registry numbers. Inst. Wakan-yaku, Toyama Med. Pharm. Univ., Toyama 930-01, Japan). Oyo Yakuri, 26(3), 461-8 (Japanese) 1983. CODEN: OYYAA2. ISSN: 0369-8033. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Influences of some b-adrenoceptor agonists including clenbuterol (I) [37148-27-9] on the gastrointestinal function were studied in rats and dogs. Clenbuterol inhibited gastric acid secretion, gastric ulcers, gastrointestinal motility, and bile secretion in the rat and pilocarpine-induced salivary secretion in the dog. The actions of other b2-agonists were similar to that of clenbuterol. .

Interaction between b2- and a2-adrenoceptor responses in the vascular system: effect of clenbuterol

Interaction between b2- and a2-adrenoceptor responses in the vascular system: effect of clenbuterol. Kazanietz, Marcelo G.; Gutkind, Jorge S.; Enero, Maria Amelia (Fac. Farm. Bioquim., UBA, Buenos Aires 1113, Argent.). Eur. J. Pharmacol., 130(1-2), 119-24 (English) 1986. CODEN: EJPHAZ. ISSN: 0014-2999. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 2 Subchronic treatment with the b2-adrenoceptor agonist clenbuterol [37148-27-9] (0.3 mg/kg-1, twice daily for 14 days) increased the median blood pressure in anesthetized normotensive rats. The treatment produced a marked redn. in the vasodilator effect of isoproterenol. Acute clenbuterol administration (0.01 mg/kg-1, i.v.) reduced the contractile response induced by the a2-adrenoceptor agonists, guanabenz or B-HT 920, and the a1- and a2-adrenoceptor agonist, clonidine, whereas it did not affect the vasoconstriction induced by the a1-adrenoceptor agonist, methoxamine, in the pithed rat. Subchronic treatment with clenbuterol attenuated the effect of the b2-adrenoceptor agonist on the vascular a2-adrenoceptor responses and enhanced the a1-adrenoceptor response to phenylephrine in pithed rats. The effect of the b2-adrenoceptor agonist was reduced by l but not d-propranolol. Apparently, subchronic treatment with clenbuterol produces a subsensitivity of the b2-adrenoceptors and reduces the interaction between b2- and a2-adrenoceptors at the vascular wall. The results may be relevant to the therapeutic effects of clenbuterol.