Detail of "3717-88-2"

CAS Number:
3717-88-2
Name:
Flavoxate hydrochloride
Molecular Structure:
Formula:
C₂₄H₂₆ClNO₄
Molecular Weight:
427.96
Synonyms:
4H-1-Benzopyran-8-carboxylicacid, 3-methyl-4-oxo-2-phenyl-, 2-(1-piperidinyl)ethyl ester, hydrochloride(9CI);1-Piperidineethanol,3-methyl-4-oxo-2-phenyl-4H-1-benzopyran-8-carboxylate (ester), hydrochloride(8CI);Bladderon;Genurin;Patricin;Peflate;Piperidinoethyl-3-methylflavone-8-carboxylate hydrochloride;Spasmal;Spasuret;Urispas;
EINECS:
223-066-4
Density:
1.203 g/cm³
Melting Point:
232-234 °C
Boiling Point:
564.1 °C at 760 mmHg
Flash Point:
294.9 °C
Solubility:
Soluble in water
Appearance:
crystalline solid
Hazard Symbols:
Xn
Risk Codes:
22-36/37/38
Safety:
26 Details

Studies on the metabolism of flavoxate hydrochloride: Studies on the metabolism of flavoxate hydrochloride. Inoue, Sho; Sugiyama, Makoto; Tatewaki, Nobukiyo; Ando, Tomini; Kono, Tatsuhiko; Fujioka, Miyuki (Res. Lab., Nippon Shinyaku Co. Ltd., Kyoto, Japan). Iyakuhin Kenkyu, 6(3), 267-76 (Japanese) 1975. CODEN: IYKEDH. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The main metabolite of flavoxate-HCl (I-HCl) [3717-88-2] in rat urine within 24 h after administration was 8-carboxy-3-methylflavone (II) [3468-01-7] and the minor metabolites were presumably 8-carboxy-3-hydroxymethylflavone (III) [66063-55-6] and conjugates of II and III. Intact I was not detected in the urine. In the dog, a small amt. of unchanged I was detected in urine. The major metabolite was II. The metabolites in rat bile were largely II and III conjugates. Differences in I metab. among several lab. animals were demonstrated.

Physicochemical properties of flavoxate hydrochloride: Physicochemical properties of flavoxate hydrochloride. Ueno, Masakazu; Kakemi, Kazuo; Matsunaga, Katuhiko; Yamane, Kimio; Ohno, Mieko (Res. Lab., Nippon Shinyaku Co., Ltd., Kyoto, Japan). Iyakuhin Kenkyu, 6(3), 249-59 (Japanese) 1975. CODEN: IYKEDH. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 64 Properties of uretic flavoxate-HCl (I) [3717-88-2], and its detn. in pharmaceutical prepns. are described. One g of the compd. dissolved in 50, 110, and 400 mL of CHCl3, H2O, and MeOH, resp., and the pKa was 7.77 at pH 7.57 in 5% EtOH. UV absorption maxima were at 241, 294, and 318 nm. I can be detd. in pharmaceutical prepns. by nonaq. titrn. with 0.05N HClO4 or by colorimetric methods.