Detail of "3736-77-4"

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CAS Number:
3736-77-4
Name:
6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one,2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-, (2R,3R,3aS,9aR)-
Superlist Name:
2,2'-Cyclouridine
Molecular Structure:
Formula:
C₉H₁₀N₂O₅
Molecular Weight:
226.19
Synonyms:
6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one,2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)- (6CI,7CI);6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one, 2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-,stereoisomer (8CI);2,2'-Anhydro(1-b-D-arabinofuranosyl)uracil;2,2'-Anhydro-N1-(b-D-arabinofuranosyl)uracil;2,2'-Anhydrouridine;2,2'-O-Cyclouridine;NSC 157148;O2,2'-Anhydrouridine;O2,2'-Cyclouridine;b-D-2',2-O-Cycloarabinouridine;
EINECS:
223-107-6
Density:
2.01 g/cm³
Melting Point:
239-240 °C
Boiling Point:
456.3 °C at 760 mmHg
Flash Point:
229.8 °C

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Reference

Structural modifications at the 2'- and 3'- positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter: Structural modifications at the 2'- and 3'- positions of some pyrimidine nucleosides as determinants of their interaction with the mouse erythrocyte nucleoside transporter. Gati, Wendy P.; Misra, Hemant K.; Knaus, Edward E.; Wiebe, Leonard I. (Fac. Pharm. Pharm. Sci., Univ. Alberta, Edmonton, AB T6G 2N8, Can.). Biochem. Pharmacol., 33(21), 3325-31 (English) 1984. CODEN: BCPCA6. ISSN: 0006-2952. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A no. of synthetic uracil and thymine nucleosides which differ from the physiol. nucleosides, uridine [58-96-8], deoxyuridine [951-78-0] and thymidine [50-89-5], through structural changes at the 2'- and 3'-positions were studied. Interaction of the analogs with the transporter was assessed in terms of their affinities for an external site on the transporter as well as their abilities to effect trans-acceleration of thymidine efflux. 1-(b-D-Arabinofuranosyl)uracil (araU) [3083-77-0] and 1-(b-D-arabinofuranosyl)thymine (araT) [605-23-2] were comparable to thymidine as permeants while nucleosides in which the 3'-hydroxyl was replaced with hydrogen or a halogen had a decreased affinity for the transporter. 3'-Fluoro-3'-deoxy-araU [19325-94-1] weakly accelerated thymidine efflux while its ribo-isomer and the other 3'-halogeno-3'-deoxyarabino analogs as well as dideoxythymidine [3416-05-5] inhibited efflux. The absence of 2'- and 3'-carbons in acyclothymidine [68724-11-8] and acyclouridine [78097-04-8] strongly decreased the affinities of these nucleosides for the transporter; efflux of thymidine was not accelerated in the presence of these compds. The conformationally constrained cyclic nucleoside 2,2'-anhydro-araU [3736-77-4] had a very low affinity for the transporter, and influx of the radiolabeled compd. could not be demonstrated. The results suggest that modification at the 3'-position, loss of a portion of the sugar ring, and lack of conformational flexibility are factors which decrease the abilities of some pyrimidine nucleosides to function as permeants. It is suggested that combined effects of substituents which play a role in detg. nucleoside conformation should be considered in assessing structural requirements for permeants of the transporter.

2',5-Dihalogenouridines: 2',5-Dihalogenouridines. Meresz, Magdolna; Kuszmann, Janos (Gyogyszerkutato Intezet, Hung.). Hung. Teljes HU 11442 28 Apr 1976, 12 pp. (Hungarian).Several reagents with their cas registry numbers 3736-77-4 and 55612-19-6 are used here. (Hungary). CODEN: HUXXBU. CLASS: IC: C07H. APPLICATION: HU 74-1295 21 Nov 1974. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) The uridines I (R, R1 = halogen) were prepd. by halogenation of 2,2'-anhydrouridine (II). Thus, II and was brominated in CHCl3 to give 42% I (R = R1 = Br), which was treated with MeONa-MeOH to give 97% 2,2'-anhydro-5-bromouridine, which was chlorinated with HCl(g) to give 52% I (R = Cl, R1 = Br). .

Detail of "3736-77-4"

6H-Furo[2',3':4,5]oxazolo[3,2-a]pyrimidin-6-one,2,3,3a,9a-tetrahydro-3-hydroxy-2-(hydroxymethyl)-, (2R,3R,3aS,9aR)-

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CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

CAS No.3736-77-4 2,2'-Cyclouridine

Reference