Detail of "37577-28-9"

Reference

Liquid chromatographic determination of the enantiomeric composition of amphetamine prepared from norephedrine and norpseudoephedrine

Liquid chromatographic determination of the enantiomeric composition of amphetamine prepared from norephedrine and norpseudoephedrine. Noggle, F. Taylor, Jr.; DeRuiter, Jack; Clark, C. Randall (Dep. Forensic Sci., Auburn, AL 36830, USA). J. Chromatogr. Sci.Some commonly used reagents like 107912-50-5 and 492-39-7 are used in this experiment., 25(1), 38-42 (English) 1987. CODEN: JCHSBZ. ISSN: 0021-9665. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 4, 25 The stereochem. course of the synthesis of amphetamine from norephedrine and norpseudoephedrine is investigated by using liq. chromatog. The results show that the chiral carbon common to both compds. remains unaffected during the reaction sequence. The presence of individual amphetamine enantiomers in the reaction products is detd. by reversed-phase liq. chromatog. sepn. on an achiral stationary phase (C18) following precolumn derivatization with 2,3,4.6-tetra-O-acetyl-b-D-glycopyranosyl isothiocyanate (GITC). The GITC derivatization procedure allows for the liq. chromatog. sepn. of the individual enantiomers (+)-amphetamine [51-64-9], (-)-amphetamine [156-34-3], (+)-norpseudoephedrine [492-39-7], (-)-norpseudoephedrine [37577-07-4], (-)norephedrine [492-41-1], and (+)-norephedrine [37577-28-9], and the intermediate 1-chloro-1-phenyl-2-aminopropanes. .

Comparison of brown adipose tissue thermogenesis induced by congeners and isomers of phenylpropanolamine

Comparison of brown adipose tissue thermogenesis induced by congeners and isomers of phenylpropanolamine. Wellman, P. J.; Marmon, M. M. (Dep. Psychol., Texas A and M Univ., College Station, TX 77843, USA). Life Sci., 37(11), 1023-8 (English) 1985. CODEN: LIFSAK. ISSN: 0024-3205. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The effects of i.p. injection of several phenethyl congeners and isomers on in vivo interscapsular brown adipose tissue (IBAT) temp. in adult male rats were compared. Comparable increases in IBAT thermogenesis were obsd. in rats treated with either d-amphetamine ((d)-AMP) [51-64-9] or dl-AMP [300-62-9] and in rats treated with either l-phenylpropranolamine ((l)-PPA) [492-41-1] or dl-PPA [14838-15-4]. d-PPA [37577-28-9] was only half as potent as l-PPA; similarly d-ephedrine ((d)-EPH) [321-98-2] was only half as potent as l-EPH [299-42-3]. There were no significant differences between the changes in IBAT thermogenesis obsd. in rats treated with d-pseudoephedrine [90-82-4] and its l-isomer [321-97-1] and d-norpseudoephedrine [492-39-7] and its l-isomer [37577-07-4]. The approx. order of potency (calcd. as the av. of the temp. changes for the isomers) for the congeners was AMP > PPA > EPH > norpseudoephedrine methoxyphenamine [93-30-1] > pseudoephedrine. The implications of these data for the wt.-reducing activity of these compds. is discussed.