Detail of "3768-56-7"

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Synthesis and some properties of trimethylsilyl-substituted (aminomethyl)phosphonites

Synthesis and some properties of trimethylsilyl-substituted (aminomethyl)phosphonites. Prishchenko, A. A.; Livantsov, M. V.; Livantsova, L. I.; Kustrya, D. N.; Grigor'ev, E. V. (Mosk. Gos. Univ., Moscow, Russia). Zhurnal Obshchei Khimii, 66(11), 1922-1923 (Russian) 1996 Nauka. CODEN: ZOKHA4. ISSN: 0044-460X. DOCUMENT TYPE: Journal CA Section: 29 (Organometallic and Organometalloidal Compounds) Heating (Me3SiO)2PH with MeOCH2N(SiMe3)2 in presence of Me3SiCl catalyst at 100-120° gave 59% Me3SiOP(O)(H)CH2N(SiMe3)2 (I). Treating I with N-(trimethylsilyl)piperidine and ZnCl2 catalyst at 120-130° or with CH2:CHCO2SiMe3 in CH2Cl2 gave 81% (Me3SiO)2PCH2N(SiMe3)2 (II) or 87% Me3SiOP(O)(CH2CH2CO2SiMe3)CH2N(SiMe3)2, resp. Reaction of II with ClCH2NR2 (NR2 = NEt2, morpholino) in CH2Cl2 gave 85, 82% of the corresponding Me3SiOP(O)(CH2NR2)CH2N(SiMe3)2.In this experiment, several chemicals are used like 13125-61-6 and 3768-56-7 Reaction of (EtO)2POSiMe3 with EtOCH2N(SiMe3)2 in presence of a catalytic amt. of ZnCl2 at 120-140° gave 78% (EtO)2P(O)CH2N(SiMe3)2. .

3-(2-Trialkylsilyloxy)ethyl-7-ethyl-1H-indoles and method for their preparation

3-(2-Trialkylsilyloxy)ethyl-7-ethyl-1H-indoles and method for their preparation. Vincenzo, Giobbio; Franco, Polastri (Teva Pharmaceutical Industries, Ltd.; Vincenzo, Giobbio; Franco, Polastri, Israel). PCT Int. Appl. WO 9638452 A1 5 Dec 1996, 16 pp. DESIGNATED STATES: W: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, NL, PT, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2.Several reagents with their cas registry numbers 18156-74-6 and 3768-56-7 are used here. CLASS: ICM: C07F007-18. ICA: C07D491-052. APPLICATION: WO 1996-EP2219 21 May 1996. PRIORITY: US 1995-453740 30 May 1995. DOCUMENT TYPE: Patent CA Section: 29 (Organometallic and Organometalloidal Compounds) Section cross-reference(s): 1, 27 3-(2-Trialkylsilyloxy)ethyl-7-ethyl-1H-indole derivs. I, wherein R1, R2 and R3 are the same or different and each is an alkyl group having from 1 to 6 carbon atoms, are prepd. and shown to be useful in the prepn. of etodolac, a known anti-inflammatory agent (no data). E.g., Me3SiNHSiMe3 was added to 7-ethyltryptophol in xylene and refluxed to give I (R1 = R2 = R3 = Me) in 48% yield. I (R1 = R2 = R3 = Me) reacted with p-toluenesulfonic acid in MeOH and water followed by treatment with Me 3-oxopentanoate in toluene/CH2Cl2 and BF2×OEt2 to give etodolac Me ester in 66% yield; this ester was added to a soln. of KOH/H2O/iPrOH and refluxed to give etodolac in 90% yield. .