Reference

Analysis of the urinary excretion of ifosfamide and its N-dechloroethylated metabolites in children using 31P-NMR spectroscopy

Analysis of the urinary excretion of ifosfamide and its N-dechloroethylated metabolites in children using 31P-NMR spectroscopy. Misiura, Konrad; Zubowska, Malgorzata; Zielinska, Elzbieta ( Department of Bioorganic Chemistry, Centre of Molecular and Macromolecular Studies, Polish Academy of Sciences, Lodz, Pol.). Arzneimittel-Forschung, 53(5), 372-377 (English) 2003 Editio Cantor Verlag. CODEN: ARZNAD. ISSN: 0004-4172. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Amts. of ifosfamide (CAS 3778-73-2) and its N-dechloroethylated metabolites excreted in the urine were measured using 31P-NMR spectroscopy in 26 cancer children treated with this drug. Strong inter-patient variation in levels of these compds. were found. These differences were independent from patients age, body surface area, and sex, the dose of the drug, suggesting genetic base of obsd. variations in ifosfamide metab.

Report on carcinogenesis bioassay of isophosphamide

Report on carcinogenesis bioassay of isophosphamide. (United States Dept. of Health, Education and Welfare; Natl. Cancer Inst., NIH, Bethesda, Md., USA). J., Am. Ind. Hyg. Assoc., 39(6), A-12, A-14, A-16 (English) 1978. CODEN: AIHAAP. ISSN: 0002-8894. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 4 Female rats treated intraabdominally with 6 or 12 mg isophosphamide (I) [3778-73-2]/kg for 52 wk and female mice treated similarly with 20 mg I/kg developed cancer while similarly treated male rats and mice did not. The female rats had a high incidence of uterine leiomyosarcoma and benign mammary tumor while the female mice had a high incidence of malignant lymphoma of the hematopoietic system.