Detail of "3778-76-5"

CAS Number:
3778-76-5
Name:
Hydrazinecarboxylicacid, 2-(1-phthalazinyl)-, ethyl ester, hydrochloride (1:1)
Superlist Name:
Todralazine hydrochloride
Molecular Structure:
Formula:
C11H12 N4 O2 . Cl H
Molecular Weight:
286.75
Synonyms:
Carbazicacid, 3-(1-phthalazinyl)-, ethyl ester, monohydrochloride (8CI);Hydrazinecarboxylic acid, 2-(1-phthalazinyl)-, ethyl ester, monohydrochloride(9CI); 2-Carbethoxy-1-(1-phthalazinyl)hydrazine hydrochloride; Apirachol;Apiracohl; Apredor; Apride; Atapren; BT 621; Binazin; Binazine; CEPH;Ecarazine; Ecarazine hydrochloride; Illcut;N-Carbethoxy-N'-(1-phthalazino)hydrazine hydrochloride;N-Carbethoxy-N'-phthalazinohydrazide hydrochloride;N1-Carboethoxy-N1-hydrazinophthalazine; Propat; Todralazine hydrochloride
Density:
1.328g/cm³
Boiling Point:
°Cat760mmHg
Flash Point:
°C
Hazard Symbols:
Risk Codes:
R20/21/22
Safety:
Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. An experimental teratogen. Mutation data reported. When heated to decomposition it emits toxic fumes of NO_x and HCl. See also ESTERS. Details

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Investigation of the mutagenic activity of some drugs manufactured by Polfa using microbial genetic methods: Investigation of the mutagenic activity of some drugs manufactured by Polfa using microbial genetic methods. Starosciak, Bohdan; Pachecka, Jan; Dobrzanski, Wladyslaw T.; Bicz, Wlodzimierz (Zakl. Mikrobiol. Farm., Akad. Med., Warsaw 02-007, Pol.). Farm.Several substances with their cas registry numbers 738-70-5 and 59-66-5 may be metioned in this study. Pol., 39(7), 399-402 (Polish) 1983. CODEN: FAPOA4. ISSN: 0014-8261. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) No mutagenic activity of astmopent [5874-97-5], Baclofen [1134-47-0], binazine [3778-76-5], chirurcoll [25154-80-7], chlorpropamide [94-20-2], clonazepam [1622-61-3], craviten [55769-64-7], diuramide [59-66-5], furosemide [54-31-9], glafenine [3820-67-5], mirenil [2376-43-4], sadamine [437-74-1], and salbutamol [18559-94-9] was obsd. in the microbial tests used. Metronidazole [443-48-1], biseptol [8064-90-2], trimethoprim [738-70-5], and butapirazole [50-33-9] were mutagenic, the latter, however, only at high concns. .

Identification of Binazine and dihydralazine by means of new color reactions: Identification of Binazine and dihydralazine by means of new color reactions. Cieszynski, Tadeusz (Biol. Pharm. Inst., Sch. Med., Poznan, Pol.). Acta Pol. Pharm., 34(2), 231-2 (Polish) 1977. CODEN: APPHAX. DOCUMENT TYPE: Journal CA Section: 64 (Pharmaceutical Analysis) When an aq. soln. of Binazine (I) [3778-76-5] was treated with 1% CuSO4 and shaken with CHCl3, a red-purple color developed in the CHCl3 layer and a blue color in the aq. layer; detectability limit was 1:500,000. In an alternative procedure, treatment with CuSO4 and pyridine gave a blue-purple color, with a detectability limit of 1:50,000. Dihydralazine (II) [484-23-1] with a satd. ethanolic soln. of NH2OH-HCl gave in the presence of NaOH a deep-red color gradually turning light yellow; the detectability limit was 1:25,000.