Products Categories
CAS No.: | 3796-24-5 |
---|---|
Name: | 4-(Trifluoromethyl)pyridine |
Article Data: | 31 |
Molecular Structure: | |
Formula: | C6H4F3N |
Molecular Weight: | 147.1 |
Synonyms: | Pyridine, 4-trifluoromethyl-; |
EINECS: | -0 |
Density: | 1.266 g/cm3 |
Boiling Point: | 141.7 °C at 760 mmHg |
Flash Point: | 39.5 °C |
Appearance: | colorless liquid |
Hazard Symbols: | F,Xi |
Risk Codes: | 11-36/37/38 |
Safety: | 16-26-36-37/60 |
Transport Information: | UN 1993 3/PG 2 |
PSA: | 12.89000 |
LogP: | 2.10040 |
1-oxido-4-(trifluoromethyl)pyridin-1-ium
4-trifluoromethylpyridine
Conditions | Yield |
---|---|
With phenylsilane; 3-Methyl-1-phenyl-2-phospholene 1-oxide In acetonitrile for 16h; Irradiation; chemoselective reaction; | 93% |
4-iodopyridine
4-trifluoromethylpyridine
Conditions | Yield |
---|---|
With copper In N,N-dimethyl-formamide at 60℃; for 11h; | 91% |
Conditions | Yield |
---|---|
With F6Mo at 170 - 190℃; for 40h; | 80% |
3-hydroxy-3-trifluoromethyl-1,5-pentanedialdehyde
4-trifluoromethylpyridine
Conditions | Yield |
---|---|
With ammonia In methanol for 24h; Heating; | 70% |
With ammonium hydroxide In methanol for 24h; Reflux; | 70% |
2-chloro-4-trifluoromethyl pyridine
4-trifluoromethylpyridine
Conditions | Yield |
---|---|
With propylamine In tetrahydrofuran at 20℃; for 15h; Reagent/catalyst; Solvent; Inert atmosphere; Irradiation; Sealed tube; | 68% |
With triethylamine; Lumogen F Orange 240 In N,N-dimethyl-formamide at 40℃; for 16h; Irradiation; | 91 %Chromat. |
With ZnSe/CdS core/shell QDs; N-ethyl-N,N-diisopropylamine In hexane at 25℃; for 48h; Irradiation; Inert atmosphere; | 23 %Chromat. |
4-iodopyridine
(trifluoromethyl)trimethylsilane
4-trifluoromethylpyridine
Conditions | Yield |
---|---|
With potassium fluoride; copper(l) iodide In 1-methyl-pyrrolidin-2-one; N,N-dimethyl-formamide at 25℃; for 6h; | 25% |
With C13H27CuN2O(1+) In N,N-dimethyl-formamide at 25℃; for 112h; | 99 %Spectr. |
pyridine
Bromotrifluoromethane
A
4-trifluoromethylpyridine
B
3-(trifluoromethyl)pyridine
C
2-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With dipotassium hydrogenphosphate; sodium dithionite In water at 65℃; under 2250.2 - 3750.3 Torr; for 2h; | A 5% B 1% C 4% |
pyridine
iodotrifluoromethane
A
4-trifluoromethylpyridine
B
3-(trifluoromethyl)pyridine
C
3,5-bis(trifluoromethyl)pyridine
D
2,6-bis-(trifluoromethyl)pyridine
E
2-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
for 96h; Product distribution; Irradiation; The yields, the kind of products depend on the time of the irrad. and/or the temp., and the mol. ratio. Other trifluorometh. agents investigated; |
4-hydroxy-4-trifluoromethyl-1,6-heptadiene
4-trifluoromethylpyridine
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 90 percent / O3 / CH2Cl2; methanol / 24 h / -78 °C 2: 70 percent / NH3 / methanol / 24 h / Heating View Scheme | |
Multi-step reaction with 2 steps 1.1: ozone / dichloromethane; methanol / -78 °C 1.2: 2 h / 20 °C 2.1: ammonium hydroxide / methanol / 24 h / Reflux View Scheme |
pyridine
Togni's reagent
A
4-trifluoromethylpyridine
B
3-(trifluoromethyl)pyridine
C
2-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
In acetonitrile at 80℃; for 96h; Inert atmosphere; | A 3 %Spectr. B 16 %Spectr. C 17 %Spectr. |
What can I do for you?
Get Best Price
Molecular Structure:
Molecular Formula: C6H4F3N
Molecular Weight: 147.0979
IUPAC Name: 4-(Trifluoromethyl)pyridine
Synonyms of 4-(Trifluoromethyl)pyridine (CAS NO.3796-24-5): Pyridine, 4-trifluoromethyl-
CAS NO: 3796-24-5
Classification Code: Pyridine series ; Pyridine ; Pyridines ; C6 ; Heterocyclic Building Blocks
Index of Refraction: 1.418
Molar Refractivity: 29.32 cm3
Molar Volume: 116.1 cm3
Surface Tension: 24.5 dyne/cm
Density: 1.266 g/cm3
Flash Point: 39.5 °C
Enthalpy of Vaporization: 36.32 kJ/mol
Boiling Point: 141.7 °C at 760 mmHg
Vapour Pressure: 7.24 mmHg at 25°C
4-(Trifluoromethyl)pyridine (CAS NO.3796-24-5) is commonly used as pharmaceutical intermediate.
Hazard Codes of 4-(Trifluoromethyl)pyridine (CAS NO.3796-24-5): F,Xi
Risk Statements: 11-36/37/38
R11: Highly flammable.
R36/37/38: Irritating to eyes, respiratory system and skin.
Safety Statements: 16-26-36-37/60
S16: Keep away from sources of ignition.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
S37: Wear suitable gloves.
S60: This material and its container must be disposed of as hazardous waste.
RIDADR: UN 1993 3/PG 2
WGK Germany: 3
Hazard Note: Irritant/Flammable
HazardClass: 3
PackingGroup: II