Detail of "38053-91-7"

Reference

Isoquinoline derivatives as cardiotonic agents

Isoquinoline derivatives as cardiotonic agents. Kaiho, Tatsuo; Otsuka, Kengo; Ito, Toshihiko; Kitano, Takashi; Maruyama, Masahiko; Hirayama, Makoto (Mitsui Toatsu Chemicals, Inc., Japan). Jpn. Kokai Tokkyo Koho JP 62019570 A2 28 Jan 1987 Showa, 7 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: C07D217-26. ICS: A61K031-47; A61K031-495; A61K031-535; C07D401-06. ICI: C07D401-06, C07D213-00, C07D217-00. APPLICATION: JP 85-158307 19 Jul 1985.Several reagents such as 112497-87-7 is used here. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1, 63 Isoquinoline derivs. I (X = CO2Et, cyano, Ac, NO2, etc.), effective cardiotonics at 0.1-10 mg/kg-day orally in adults, are prepd. Diels-Alder reaction of 6.2 g H2C:C(OSiMe3)CH:CH2 with 4.0 g Et acrylate in MePh followed by acetylation gave 3.6 g cyclohexanone deriv. II, which (3.6 g) was refluxed with 1.4 g NCCH2CONH2 in EtOH to give 1.3 g I (X = CO2Et). A tablet formulation was made from I 50, lactose 38, corn starch 35, cellulose 20, and (hydroxypropyl)cellulose 5 g. .

Dioxopyrroline

Dioxopyrroline. L. Skeletal rearrangements of 7-vinyl-7-trimethylsilyloxy-5-ethoxycarbonyl-1-phenyl-2-azabicyclo[3.2.0] heptane-3,4-diones under thermal, basic, and acidic conditions. Sano, Takehiro; Toda, Jun; Tsuda, Yoshisuke (Showa Coll. Pharm. Sci., Machida 194, Japan).Some commonly used reagents like 140851-99-6 and 38053-91-7 are used in this experiment. Chem. Pharm. Bull., 40(1), 36-42 (English) 1992. CODEN: CPBTAL. ISSN: 0009-2363. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 31 The oxyvinylcyclobutanes I (R = H, Me; R1 = H, MeO), photoadducts of the dioxopyrrolines to trimethylsilyloxybutadienes, undergo two different types of skeletal rearrangements depending on the reaction conditions. Thermolysis caused expansion of the cyclobutane ring by a 1,3-shift of the C(1)-C(7) bond toward the vinyl group, giving rise to the hydroindoles II in moderate yields. This 1,3-shift was enormously accelerated when an alkoxide was generated by the action of Bu4N+F- on trimethylsilyloxyvinylcyclobutanes. Thus, on treatment of I with Bu4N+F- at -30°, provided hydroindole III in good yields, though in some cases accompanied with byproducts. This demonstrates that the [2 + 2] photoannulation of dioxopyrroline, when coupled with the anionic 1,3-shift provides an efficient synthetic route to functionalized hydroindoles. Under acidic conditions, I rearranged to give exclusively the 2-azatricyclo[4.3.0.04,9]nonanes IV, whose formation was rationalized in terms of the intramol. Prins-type cyclization with concomitant expansion of the cyclobutane ring by 1,2-shift of the C(1)-C(7) bond toward the vinyl group. .