Detail of "3810-80-8"

Reference

Determination of ionization constants in mixed aqueous solvents of varying composition by a single titration

Determination of ionization constants in mixed aqueous solvents of varying composition by a single titration. Peeters, Jef (Phys.-Chem. Dep., Janssen Pharm., Beerse, Belg.). J. Pharm. Sci., 67(1), 127-9 (English) 1978. CODEN: JPMSAE. ISSN: 0022-3549. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 22 A potentiometric titrn. method is proposed in which only 1 titrn. is necessary to obtain pK'a values for different solvent compns. The method allows the results to be extrapolated to the value for pure water. PKa values detd. by the proposed method compared to values detd. by other methods were: seperidol-HCl [17230-87-4] 8.43, 8.44; cinnarizine [298-57-7] 7.47, 7.60; diphenoxylate-HCl [3810-80-8] 7.07, -; etomidate sulfate [51919-80-3] -, 4.24; miconazole nitrate [22832-87-7] 6.91, 6.65. The advantages and disadvantages of the method are discussed.

On the antidiarrhoeal and analgesic properties of diphenoxylate, difenoxine and loperamide in mice and rats

On the antidiarrhoeal and analgesic properties of diphenoxylate, difenoxine and loperamide in mice and rats. Bianchi, C.; Goi, A. (Res. Lab., Soc. Prod. Antibiot., Milan, Italy). Arzneim.-Forsch., 27(5), 1040-3 (English) 1977. CODEN: ARZNAD. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Diphenoxylate-HCl (I-HCl) [3810-80-8] and difenoxine-HCl (II-HCl) [35607-36-4] (which were structurally related to the narcotic analgesic meperidine) possessed both antidiarrheal and analgesic effects that could not be sepd. by any of the tests used to measure these properties. In contrast, loperamide-HCl (III-HCl) [34552-83-5] (which was unrelated to any narcotics) showed antidiarrheal activity that was not assocd. with analgesic effects in all tests. In order to avoid potential addiction problems, care must be taken in the development of antidiarrheal agents related to mols. with central analgesic effects.