Detail of "383-70-0"

Reference

Phosphorus analogs of amino acids and peptides

Phosphorus analogs of amino acids and peptides.Several substances are used for example 88185-32-4 and 383-70-0 which are their cas registry numbers. IX. Phosphonate analogs of amino acids and peptides: synthesis of phosphonate analogs of depsipeptides by the Passerini reaction. Rachon, Janusz (Inst. Org. Chem., Tech. Sch., Gdansk, Pol.). Chimia, 37(8), 299-301 (German) 1983. CODEN: CHIMAD. ISSN: 0009-4293. DOCUMENT TYPE: Journal CA Section: 34 (Amino Acids, Peptides, and Proteins) Depsipeptide phosphonate analogs RR1NCH2CO2CHR2CONHCH2P(O)(OEt)2 (R = H, R1 = Ac, CF3CO, PhCH2O2CNHCH2CO, Ph3CNHCH2CO; R1R1N = phthalimido; R2 = Me2CH, Ph) were prepd. in 66-92% yields by Passerini reaction of RR1NCH2CO2H with R2CHO and CNCH2P(O)(OEt)3. .

Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones

Structure-activity relationship in the gastric cytoprotective effect of several sesquiterpene lactones. Giordano, Oscar S.; Pestchanker, Mauricio J.; Guerreiro, Eduardo; Saad, Jose R.; Enriz, Ricardo D.; Rodriguez, Ana M.; Jauregui, Esteban A.; Guzman, Jorge; Maria, Alejandra O. M.; Wendel, Graciela H. (Dep. Quim. Org., Univ. Nac. San Luis, San Luis 5700, Argent.). J. Med. Chem., 35(13), 2452-8 (English) 1992. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 30 The structural requirements for the gastric cytoprotective activity of several sesquiterpene lactones are reported. A theor.-exptl. study on the potentially active centers is carried out. The biol. evaluation of reduced analogs and the simulation of the mol. interactions between these compds. 383-70-0 which is the cas registry number of one of substances is just one of reagents here. and an endogenous cysteine residue suggest that the presence of a non sterically hindered Michael acceptor seems to be an essential structural requirement for the cytoprotective activity in this family of compds. This observation suggests that cytoprotection is mediated through a Michael reaction between the sulfhydryl-contg. peptides of the mucosa and Michael acceptors present in the mols. under study. This mechanism of action is in addn. to and distinct from the one proposed previously, namely, that these sesquiterpenes stimulate endogenous synthesis of prostaglandins. .