Reference

Conversion of anhydrovinblastine into vinblastine in Catharanthus roseus tissue culture

Conversion of anhydrovinblastine into vinblastine in Catharanthus roseus tissue culture. Hasan, Mashooda (Dep. Chem., Quaid-i-Azam Univ., Islamabad, Pak.). Nat. Prod. Chem., Proc. Int. Symp. Pak.-U.S. Binatl. Workshop, 1st, Meeting Date 1984, 121-32. Edited by: Rahman, Atta Ur. Springer: Berlin, Fed. Rep. Ger. (English) 1986. 865-21-4 and 38390-45-3 which are cas registry numbers of chemicals are mentioned. CODEN: 55JSAT. DOCUMENT TYPE: Conference CA Section: 16 (Fermentation and Bioindustrial Chemistry) A cell culture of C. roseus converted anhydrovinblastine (I) [38390-45-3] to vinblastine II [865-21-4]. Cell-free exts. of C. roseus also converted I to II. The kinetics of the reaction in both systems (cell culture and cell-free ext.) are detailed and discussed. .

Total synthesis of indole and dihydroindole alkaloids

Total synthesis of indole and dihydroindole alkaloids. IX. Studies on the synthesis of bisindole alkaloids in the vinblastine-vincristine series. The biogenetic approach. Kutney, James P.; Hibino, Toshihiko; Jahngen, Edwin; Okutani, Tetsuya; Ratcliffe, Arnold H.; Treasurywala, Adi M.; Wunderly, Stephen (Dep. Chem., Univ. British Columbia, Vancouver, B. C., Can.). Helv.Several substances with their cas registry numbers 38390-45-3 and 62069-69-6 may be metioned in this study. Chim. Acta, 59(8), 2858-83 (English) 1976. CODEN: HCACAV. DOCUMENT TYPE: Journal CA Section: 31 (Alkaloids) The reaction of catharanthine N-oxide and vindoline was carried out at various conditions. Under optimum conditions, which involve low temp. in (F3CCO)2O gave 3',4'-dehydrovinblastine I (R1 = R, R2 = CO2Me, R3 = H) as the exclusive product. I (R1 = CO2Me, R2 = R, R3 = H) and I (R1 = R, R2 = CO2Me, R3 = OH) were often isolated. The reaction, which follows the course of a Polonovski fragmentation process, was extended to the N-oxide derivs. of dihydrocatharanthine and decarbomethoxycatharanthine to give bisindole alkaloid derivs. .