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3844-53-9

Basic Information
CAS No.: 3844-53-9
Name: Ethyl 2,6-diaminohexanoate dihydrochloride
Article Data: 5
Molecular Structure:
Molecular Structure of 3844-53-9 (Ethyl 2,6-diaminohexanoate dihydrochloride)
Formula: C8H18 N2 O2 . 2 Cl H
Molecular Weight: 247.165
Synonyms: L-Lysine,ethyl ester, dihydrochloride (9CI); Lysine, ethyl ester, dihydrochloride, L-(7CI,8CI); Lysine ethyl ester dihydrochloride; NSC 162742
EINECS: 223-340-3
Density: g/cm3
Melting Point: ~150 °C (dec.)
Boiling Point: 261.9 °C at 760 mmHg
Flash Point: 97.3 °C
Appearance: White Powder
Hazard Symbols: 36/37/38:;
Risk Codes: 36/37/38
Safety: 22-24/25
PSA: 78.34000
LogP: 3.01040
Synthetic route
64-17-5

ethanol

657-27-2, 10098-89-2

L-Lysine hydrochloride

3844-53-9

L-lysine ethyl ester dihydrochloride

Conditions
ConditionsYield
With thionyl chloride Reflux;87%
With thionyl chloride at -10℃; for 6h; Reflux;87%
With hydrogenchloride at 70℃; for 5h;
64-17-5

ethanol

L-lysine-dihydrochloride

L-lysine-dihydrochloride

3844-53-9

L-lysine ethyl ester dihydrochloride

Conditions
ConditionsYield
With hydrogenchloride

C11H15N2O5PolS

3844-53-9

L-lysine ethyl ester dihydrochloride

C22H38N4O6Pol2S2

Conditions
ConditionsYield
Stage #1: C11H15N2O5PolS With benzotriazol-1-ol; dicyclohexyl-carbodiimide In dichloromethane at 20℃; for 3h;
Stage #2: L-lysine ethyl ester dihydrochloride With dmap In dichloromethane at 20℃; for 42h;
94%
3844-53-9

L-lysine ethyl ester dihydrochloride

76-83-5

trityl chloride

ethyl 2-amino-6-(tritylamino)hexanoate

Conditions
ConditionsYield
With triethylamine In dichloromethane at 20℃; for 6h;88.8%
1521-38-6

2,3-dimethoxybenzoic acid

3844-53-9

L-lysine ethyl ester dihydrochloride

ethyl N2,N6-bis(2,3-dimethoxybenzoyl)-L-lysinate

Conditions
ConditionsYield
With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; N-ethyl-N,N-diisopropylamine In N,N-dimethyl-formamide at 20℃; for 16h; Inert atmosphere;85%
3844-53-9

L-lysine ethyl ester dihydrochloride

552-30-7

trimellitic Anhydride

1281900-48-8

C26H22N2O10

Conditions
ConditionsYield
With pyridine; acetic acid at 20℃; for 6h; Reflux;79%
With pyridine; acetic acid for 8h; Reflux;
16024-56-9

2-(2-methoxyethoxy)acetic acid

3844-53-9

L-lysine ethyl ester dihydrochloride

di-(2-methoxyethoxyacetyl)-L-lysine ethyl ester

Conditions
ConditionsYield
With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate In N,N-dimethyl-formamide at 20℃; Cooling with ice;77.8%
3844-53-9

L-lysine ethyl ester dihydrochloride

30562-34-6

geldanmycin

(S)-ethyl 2-amino-6-(((4E,6Z,8S,9S,10E,12S,13R,14S,16R)-9-(carbamoyloxy)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-19-yl)amino)hexanoate

Conditions
ConditionsYield
With triethylamine In tetrahydrofuran; methanol at 60℃;74.1%
3844-53-9

L-lysine ethyl ester dihydrochloride

1010-93-1

2-methyl-5-nitroimidazole-1-acetic acid

ethyl 2,6-bis(2-(2-methyl-5-nitro-1H-imidazol-1-yl)acetamido)hexanoate

Conditions
ConditionsYield
Stage #1: 2-methyl-5-nitroimidazole-1-acetic acid With 1,1'-carbonyldiimidazole In N,N-dimethyl-formamide for 0.25h; Inert atmosphere;
Stage #2: L-lysine ethyl ester dihydrochloride With triethylamine In N,N-dimethyl-formamide Inert atmosphere;
69%

C29H51NO15

3844-53-9

L-lysine ethyl ester dihydrochloride

870821-07-1

C52H102N2O26

Conditions
ConditionsYield
With triethylamine In N,N-dimethyl-formamide at 20℃;66%
Raw Materials
657-27-2
64-17-5
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    Synonyms: LYSINE-OET 2 HCL;L-LYSINE ETHYL ESTER DIHYDROCHLORIDE;H-LYS-OET 2HCL;ethyl L-lysinate dihydrochloride;L-Lysine Ethyl Ester 2HCl;L-LYSIN-ETHYLESTER-DIHYDROCHLORID;L-Lysine ethyl ester dihy;L-Lysine ethyl·dihydrochloride CAS: 3844-5

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Chemistry

Molecular Formula :C8H20Cl2N2O2
Molecular Weight 247.1
Purity >98.0%
Appearance White powder
Melting point: ~150 °C (dec.)
Storage temp:-20°C
Sensitive  Hygroscopic

Toxicity Data With Reference

H-Lys-OEt-2HCl is irritate to skin and mucous membrane.And H-Lys-OEt-2HCl can  induce breathing disorders.

Safety Profile

Risk Statements  36/37/38
Safety Statements  22-24/25