Reference

Flunixin and its use in the horse

Flunixin and its use in the horse. Jaussaud, P. (Lab. Xenobiot. Cheval de Sport, Ec. Natl. Vet. Lyon, Charbonnieres 69752, Fr.). Ann. Rech. Vet., 17(4), 353-62 (French) 1986. CODEN: ARCVBP. ISSN: 0003-4193. DOCUMENT TYPE: Journal; General Review CA Section: 1 (Pharmacology) Section cross-reference(s): 4 A review, with 42 refs., describing the physiochem. properties of flunixin [38677-85-9] and its pharmacol. and toxicol. in the horse, including its abuse as a doping agent.

Determination of flunixin in equine plasma by reversed-phase liquid chromatography

Determination of flunixin in equine plasma by reversed-phase liquid chromatography. Johansson, I. Monika; Schubert, Bertil (Fac. Vet. Med., Swed. Univ. Agric. Sci., Uppsala S-751 23, Swed.). J. Pharm. Biomed. Anal., 2(3-4), 501-8 (English) 1984. CODEN: JPBADA. ISSN: 0731-7085. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Flunixin (I) [38677-85-9] is detd. in equine plasma by liq. chromatog. on LiChrosorb RP-18 with 70% MeOH in phosphate buffer pH 3.1 as the eluent and with detection at 284 nm. Plasma is deproteinized with MeOH and the supernatant is then injected directly into the system. With a short precolumn (5 ′ 3 mm internal diam.), which is replaced after 25-40 injections of sample, 420 plasma samples could be analyzed on one anal. column. The detection limit in plasma is 0.30 mmol/L (89 ng/mL) and the method can be used in pharmacokinetic studies.