Reference

Preparation of benzimidazoles as modulators of the GABAA receptor complex

Preparation of benzimidazoles as modulators of the GABAA receptor complex. Teuber, Lene; Waetjen, Frank; Fukuda, Yoshimasa; Ushiroda, Osamu; Sasaki, Toshiro (Neurosearch A/s; Meiji Seika Kaisha, Ltd.; Teuber, Lene; Waetjen, Frank; Fukuda, Yoshimasa; Ushiroda, Osamu; Sasaki, Toshiro, Den.). PCT Int. Appl. WO 9633194 A1 24 Oct 1996, 55 pp. DESIGNATED STATES: W: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, NL, PT, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D405-14. ICS: A61K031-415; A61K031-42; A61K031-34; C07D413-14; C07D417-14; C07D521-00. APPLICATION: WO 1996-EP1606 17 Apr 1996. PRIORITY: DK 1995-460 21 Apr 1995. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 The title compds. [I; R1, R2 = H, (un)substituted furanyl, isoxazolyl; R3 = II (wherein A, B, D = each CH, or one or two of A, B and D = N and the others are CH; R4 = (un)substituted Ph, benzimidazolyl, or monocyclic heteroaryl)], useful for the treatment of various CNS disorders such as epilepsy and other convulsive disorders, anxiety, sleep disorders and memory disorders, were prepd. Thus, cyclization of N-[3-(1-imidazolyl)phenyl]-2-amino-4-(3-furanyl)aniline with HCOOH afforded 84% I [R1 = 3-furanyl; R2 = H; A, B, D = CH; R4 = 1-imidazolyl] which showed IC50 of 0. 184097-62-9 and 38696-21-8 are just another two chemicals used in this study.4 nM against the specific binding of 3H-FNM. .