CAS No.3874-54-2,1-Butanone,4-chloro-1-(4-fluorophenyl)- Suppliers

Detail of "3874-54-2"

CAS Number:

3874-54-2

Name:

1-Butanone,4-chloro-1-(4-fluorophenyl)-

Superlist Name:

4-Chloro-4'-fluorobutyrophenone

Molecular Structure:

Formula:

C₁₀H₁₀ClFO

Molecular Weight:

200.64

Deleted CAS:

41167-07-1|660844-72-4

Synonyms:

Butyrophenone,4-chloro-4'-fluoro- (6CI,7CI,8CI);1-Chloro-4-(4-fluorophenyl)-4-oxobutane;3-(p-Fluorobenzoyl)propyl chloride;4-(4-Fluorophenyl)-4-oxobutyl chloride;4-Chloro-1-(4-fluorophenyl)-1-butanone;4-Chloro-1-(p-fluorophenyl)-1-oxobutane;4-p-Fluorophenyl-4-oxo-1-chlorobutane;4'-Fluoro-4-chlorobutyrophenone;p-Fluoro-4-chlorobutyrophenone;g-Chloro-p-fluorobutyrophenone;w-Chloro-p-fluorobutyrophenone;

EINECS:

223-395-3

Density:

1.183 g/cm³

Melting Point:

5-6 °C

Boiling Point:

299.1 °C at 760 mmHg

Flash Point:

134.7 °C

Solubility:

water: 0.38 g/L (20 °C)

Appearance:

slightly yellow-greenish clear oil

Hazard Symbols:

Xn,

Risk Codes:

22-36/37/38-20/21/22

Safety:

24/25-36-26 Details

Reference

Treating cardiac arrhythmia with: Treating cardiac arrhythmia with .gamma.-piperidinobutyrophenones. Hernestam, Sven Eric Harry; Petersen, Erling Niels (Den. ). U.S. US 4021563 3 May 1977,5 pp. (English). (United States of America). CODEN: USXXAM. CLASS: IC: A61K031-445. NCL: 424267000. PRIORITY: GB 75-5030 6 Feb 1975. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 27 Compns. contg. substituted .gamma.-piperidinobutyrophenones I (R1 and R2 are, independently, H or lower alkyl) or their acid addn. salts are used for the therapeutic and prophylactic treatment of cardiac arrhythmias. The compns. are nontoxic and can be administered orally or parenterally. I are prepd. by reacting a piperidine, which is alkylated in the para position, with .gamma.-halo-p-fluorobutyrophenone, or by a Grignard reaction between the appropriate 4-alkylpiperidinobutyronitrile and p-fluorobromobenzene [460-00-4]. For example, 4-fluoro-.gamma.-(4-ethyl-4-propylpiperidino)butyrophenone (I, R1 = Et, R2 = Pr) [63253-47-4] was prepd. by reacting . 63253-54-3 which is the cas registry number of one of substances is just one of reagents here.gamma.-chloro-p-fluorobutyrophenone [3874-54-2] with 4-ethyl-4-propylpiperidine [63550-97-0] at an elevated temp. in the presence of an acid binding agent. The hydrochloride [63253-55-4] was prepd. from the free base and formulated into tablets contg. the hydrochloride 5, Mg stearate 3, cellulose powder 6, talcum 3, lactose 143, and Aerosil 1 mg. .

4-(4-Diphenylmethylenepiperidino)butan-1-one derivatives: 4-(4-Diphenylmethylenepiperidino)butan-1-one derivatives. Carr, Albert A.; Kinsolving, Clyde R. 43076-44-4 and 3874-54-2 are also occured in this study. (Richardson-Merrell Inc., USA). Ger. Offen. DE 2365896 30 Sep 1976, 14 pp. (German). (Germany). CODEN: GWXXBX. CLASS: IC: C07D211-70. PRIORITY: US 72-221820 28 Jan 1972. DOCUMENT TYPE: Patent CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Piperidinobutanone derivs. (I; R = 4-FC6H4, 2-thienyl, Ph, 4-BrC6H4, 4-Me3CC6H4, 4-MeOC6H4), useful as antihistaminics, allergy inhibitors, and bronchodilators, are prepd. by condensation of 4-(diphenylmethylene)piperidine (II) with 4-halobutyrophenones or by dehydration of the appropriate 4-(hydroxydiphenylmethyl)piperidine derivs. Thus, treating 99.9g II with 88g Cl(CH2)3COC6H4F-4 and 64g KHCO3 for 5 days in refluxing PhMe in presence of KI gave I (R = 4-FC6H4). .

Detail of "3874-54-2"

1-Butanone,4-chloro-1-(4-fluorophenyl)-

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CAS No.3874-54-2 4-Chloro-4'-fluorobutyrophenone

CAS No.3874-54-2 4-Chloro-4'-fluorobutyrophenone

CAS No.3874-54-2 4-Chloro-4'-fluorobutyrophenone

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CAS No.3874-54-2 4-Chloro-4'-fluorobutyrophenone

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CAS No.3874-54-2 4-Chloro-4'-fluorobutyrophenone

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CAS No.3874-54-2 4-Chloro-4'-fluorobutyrophenone

Reference