Products Categories
CAS No.: | 387827-64-7 |
---|---|
Name: | 2-(2,4-difluorophenyl)-5-(trifluoroMethyl)pyridine |
Article Data: | 20 |
Molecular Structure: | |
Formula: | C12H6F5N |
Molecular Weight: | 259.178 |
Synonyms: | 5-(trifluoromethyl)-2-(2,4-difluorophenyl)pyridine;Pyridine,2-(2,4-difluorophenyl)-5-(trifluoromethyl);2-(2,4-difluorophenyl)-5-trifluoromethylpyridine; |
Density: | 1.364±0.06 g/cm3(Predicted) |
Melting Point: | 59.0-62.1°C |
Boiling Point: | 253.4±35.0 °C(Predicted) |
PSA: | 12.89000 |
LogP: | 4.04560 |
2-bromo-5-(trifluoromethyl)pyridine
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 24h; Suzuki Coupling; Inert atmosphere; Sealed tube; | 98% |
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water at 80℃; for 24h; | 98% |
2,4-difluorophenylboronic acid
2-bromo-5-(trifluoromethyl)pyridine
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With tetrakis(triphenylphosphine) palladium(0); potassium carbonate In tetrahydrofuran; water for 36h; Reflux; Inert atmosphere; | 95% |
With potassium phosphate; methanesulfonic acid(2-dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)[2-(2′-amino-1,1′-biphenyl)]palladium(II) In tetrahydrofuran; water at 40℃; for 4h; Inert atmosphere; | 95% |
With palladium diacetate; potassium carbonate; triphenylphosphine In ethanol; water; toluene Inert atmosphere; Reflux; | 86% |
2-chloro-5-trifluoromethylpyridine
2,4-difluorophenylboronic acid
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
Conditions | Yield |
---|---|
With PdCl(dppb)(C3H5); potassium carbonate In methanol; water; toluene at 110℃; for 16h; Inert atmosphere; Schlenk technique; | 82% |
With palladium diacetate; potassium carbonate; triphenylphosphine In 1,2-dimethoxyethane Suzuki Coupling; Inert atmosphere; Reflux; | 79% |
With tetrakis(triphenylphosphine) palladium(0); sodium carbonate In water; toluene; benzene for 48h; Inert atmosphere; | 77% |
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
bis-(μ)-chlorotetrakis[2-(2’,4’-difluorophenyl)-5-trifluoromethylpyridinato]-(C2,N)diiridium(III)
Conditions | Yield |
---|---|
Stage #1: 2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine; bis-(μ)-chlorotetrakis[2-(2’,4’-difluorophenyl)-5-trifluoromethylpyridinato]-(C2,N)diiridium(III) In ethylene glycol at 150℃; Stage #2: ammonium hexafluorophosphate In dichloromethane; ethylene glycol Further stages; | 95% |
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
bis-(μ)-chlorotetrakis[2-(2’,4’-difluorophenyl)-5-trifluoromethylpyridinato]-(C2,N)diiridium(III)
Conditions | Yield |
---|---|
In 2-ethoxy-ethanol; water at 150℃; for 16h; Inert atmosphere; | 86% |
In 2-ethoxy-ethanol; water at 120℃; for 20h; Inert atmosphere; | 84% |
In 2-ethoxy-ethanol; water at 120℃; Inert atmosphere; | 70% |
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
bis-(μ)-chlorotetrakis[2-(2’,4’-difluorophenyl)-5-trifluoromethylpyridinato]-(C2,N)diiridium(III)
Conditions | Yield |
---|---|
In 2-ethoxy-ethanol; water at 150℃; for 16h; Inert atmosphere; | 86% |
In 2-ethoxy-ethanol; water at 135℃; Inert atmosphere; | 81% |
In 2-ethoxy-ethanol; water at 120℃; | 70% |
In 2-ethoxy-ethanol; water at 120℃; Inert atmosphere; | |
In 2-ethoxy-ethanol; water at 100℃; for 24h; |
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
bis-(μ)-chlorotetrakis[2-(2’,4’-difluorophenyl)-5-trifluoromethylpyridinato]-(C2,N)diiridium(III)
Conditions | Yield |
---|---|
In 2-ethoxy-ethanol; water at 150℃; for 16h; Inert atmosphere; | 86% |
In 2-methoxy-ethanol; water at 120℃; Inert atmosphere; |
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
bis-(μ)-chlorotetrakis[2-(2’,4’-difluorophenyl)-5-trifluoromethylpyridinato]-(C2,N)diiridium(III)
Conditions | Yield |
---|---|
In 2-methoxy-ethanol; water mixt. of 2.1 equiv. of pyridine deriv. and iridium compd. (ratio = 3:1) in 2-methoxyethanol/water heated at 125°C for 18 h; cooling, addn. of water, solid vac.-filtered, washed with water and hexane, dried under vac.; |
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
[Ir(CF3(C5H3N)(C6H2F2))2Cl]2
Conditions | Yield |
---|---|
In 2-ethoxy-ethanol; water org. ligand (2.2 equiv.) and IrCl3*3H2O (1 equiv.) in 2-ethoxyethanol:H2O (3:1) refluxed (24 h); ppt. collected by filtration; washed with H2O and Et2O; |
potassium hexafluorophosphate
dichloro(benzene)ruthenium(II) dimer
2-(2',4'-difluorophenyl)-5-(trifluoromethyl)pyridine
acetonitrile
[Ru(2-(2,4-difluorophenyl)-5-trifluoromethylpyridine)(acetonitrile)4]PF6
Conditions | Yield |
---|---|
With NaOH In acetonitrile under N2, 45°C, 15 h; filtered on Al2O3 (CH2Cl2/MeCN as eluent), yellow fraction dried (vac.),dissolved in CH2Cl2, pptd. by Et2O/hexane; elem. anal.; |