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Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in an immediate-release layer with levodopa ethyl ester in a controlled release core

Dual release formulation comprising levodopa ethyl ester and a decarboxylase inhibitor in an immediate-release layer with levodopa ethyl ester in a controlled release core. Licht, Daniela; Patashnik, Shulamit; Naftali, Ezmira; Sayag, Naim; Gilbert, Adrian; Cohen, Sasson; Zollmann, Corinne (Teva Pharmaceutical Industries, Ltd.; Teva Pharmaceuticals USA, Inc., Israel). PCT Int. Appl. WO 2003005968 A2 23 Jan 2003, 77 pp. DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K. APPLICATION: WO 2002-US22207 12 Jul 2002. PRIORITY: US 2001-PV305179 12 Jul 2001; US 2002-PV346719 7 Jan 2002. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) A tablet which comprises an inner core formulated for controlled release consisting essentially of a mixt. of levodopa Et ester or a deriv. or a pharmaceutically acceptable salt thereof, a carrier and an inner core excipient; and an outer layer encapsulating the inner core and formulated for immediate release comprising a mixt. of a decarboxylase inhibitor and levodopa Et ester or a deriv. or a pharmaceutically acceptable salt thereof. The subject invention also encompasses a method of treating patients suffering from Parkinson's disease or related disorders by the administration of the pharmaceutical compns. of the subject invention.In this experiment, several chemicals are used like 9005-25-8 and 38821-49-7 The subject invention also provides methods of manufg. the tablets of the subject invention. .