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Detail of > 389-08-2

  • CAS Number:
  • 389-08-2
  • Name:
  • 1,8-Naphthyridine-3-carboxylicacid, 1-ethyl-1,4-dihydro-7-methyl-4-oxo-

  • Superlist Name:
  • Nalidixic acid
  • Formula:
  • C12H12N2O3
  • Molecular Structure:
  • Synonyms:
  • 1,4-Dihydro-1-ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylicacid;1-Ethyl-7-methyl-1,8-naphthyridin-4-one-3-carboxylic acid;1-Ethyl-7-methyl-4-oxo-1,8-naphthyridine-3-carboxylic acid;3-Carboxy-1-ethyl-7-methyl-1,8-naphthyridin-4-one;Betaxina;Dixiben;Eucistin;Innoxalomn;Nalidicron;Nalidixan;Nalidixin;Nalitucsan;Nalurin;Nelidix;Nevigramon;Poleon;Specifin;Urisal;Uroman;Wintomylon;
  • Molecular Weight:
  • 232.23
  • EINECS:
  • 206-864-7
  • Density:
  • 1.331 g/cm3
  • Melting Point:
  • 227-229 °C(lit.)
  • Boiling Point:
  • 413.1 °C at 760 mmHg
  • Flash Point:
  • 203.6 °C
  • Solubility:
  • 0.1 g/L (23 °C) in water
  • Appearance:
  • crystalline powder
  • Hazard Symbols:
  • HarmfulXn
  • Risk Codes:
  • 63-42/43-40-20/21/22
  • Safety:
  • 22-36/37-45-24-36Details
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389-08-2 Nalidixic acid

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Nalidixic acid
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Nalidixic Acid, USP
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389-08-2 Nalidixic acid

Nalidixic acid(NegGram) is a synthetic 1,8-naphthyridine antimicrobial agent with a limited bacteriocidal spectrum. It is an inhibitor of the A subunit of bacterial DNA gyrase.
United States   52
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389-08-2 Nalidixic acid

BRAND NAME Anti-Bacterials PRODUCT NAME CSFC 232 MOLECULAR FORMULAR C12H12N2O3 APPLICATIONS It is a high efficient pharmaceutical drug against gram-negative bacterials CHEMICAL NAME 1-Ethyl-1,4-dihydro-7-methyl-4-oxo-1,8-naphthyridine-3- carboxylic acid CAS NUMBER 389-0
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NALIDIXIC ACID
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    Reference

    Effects of oxolinic acid on the sweetfish in Lake Hamana, Japan
    Effects of oxolinic acid on the sweetfish in Lake Hamana, Japan. Ai, Takao; Ushiyama, Munehiro (Suisan Shikenjo, Japan). Shizuoka-ken Suisan Shikenjo Jigyo Hokoku, Volume Date 1973 171-2 (Japanese) 1974. CODEN: SSJHAI. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Oxolinic acid (I) [14698-29-4] added to a culture medium of sweetfish at 2 ppm prevented the occurrence of Vibrio infection, but nalidixic acid [389-08-2] similarly used was not effective.
    Changes in the ratio of activity of reparative and replicative enzymes of DNA synthesis as a basis for the search for radioprotective drugs
    Changes in the ratio of activity of reparative and replicative enzymes of DNA synthesis as a basis for the search for radioprotective drugs. Filippovich, I. V.; Romantsev, E. F. (Inst. Biophys., Moscow, USSR). Modif. Radiosensitivity Biol. Syst., Proc. Advis. Group Meet., Meeting Date 1975, 205-6. IAEA: Vienna, Austria. (English) 1976. CODEN: 35WGA2. DOCUMENT TYPE: Conference CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 8 Preincubation of thymocytes with specific inhibitors of replication DNA polymerase [9012-90-2] [nalidixic acid (I) [389-08-2] or 1-.beta.-D-arabinofuranosylcytosine [147-94-4]] protected the cells against radiation damage. The effect was attributed to temporary inhibition of DNA replication while DNA repair proceded.

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