Detail of "390-64-7"

CAS Number:
390-64-7
Name:
Benzenepropanamine,N-(1-methyl-2-phenylethyl)-g-phenyl-
Molecular Structure:
Formula:
C24H27 N
Molecular Weight:
329.52
Synonyms:
Prenylamine (vasodilator);SAN13-194;Sandoz 13-194;Segontin;N-(3,3-Diphenylpropyl)-a-methylphenethylamine;Prenylamine;N-(3,3-Diphenylpropyl)-a-methylphenylethylamine;DL-Prenylamine;Elecor;B 436;Phenethylamine,N-(3,3-diphenylpropyl)-a-methyl- (6CI,8CI);
Density:
1.023g/cm³
Boiling Point:
476.1°Cat760mmHg
Flash Point:
219.4°C
Safety:
Poison by intravenous route. Human systemic effects by ingestion: arrythmia. Experimental teratogenic and reproductive effects. When heated to decomposition it emits toxic fumes of NO_x. Details

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Package:46 kg/vacuum...Storage:store at RT Transportation:by sea/air Application:Prenylamine

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Stereological quantification of cardiac muscle fiber necroses, a method for pathological physiology and pharmacology: Stereological quantification of cardiac muscle fiber necroses, a method for pathological physiology and pharmacology. Leder, O. (Anat. Inst., Freiburg/Br., Ger.). Prakt. Metallogr., Sonderb., 5(Quant. Anal. Mikrostrukt. Med., Biol. Materialentwickl., Ber. Symp. "Quant. Gefuegeanal."), 129-39 (German) 1975. CODEN: PMSODC. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 14 Isoproterenol-HCl-induced myocardial necrosis in rats was inhibited by the Ca2+ antagonists, verapamil-HCl [152-11-4], D-600 [16662-47-8], prenylamine [390-64-7] or calcitonin [9007-12-9] given s.c. or by KCl and(or) MgCl2 given orally. It was enhanced by 9.alpha.-fluorocortisol acetate [514-36-3]. Verapamil and D-600 protected the animals from the potentiating effect of 9.alpha.-fluorocortisol, indicating that Ca2+ are essential for the necrosis-potentiating effect.

Data referring to the dissolution kinetics of some up-to-date drugs: Data referring to the dissolution kinetics of some up-to-date drugs. Csontos, Andras; Racz, Istvan; Gyarmati, Laszlo (Gyogyszertani Intez., Semmelweis Orvostud. Egy., Budapest, Hung.). Acta Pharm. Hung., 47(4), 155-61 (Hungarian) 1977. CODEN: APHGAO. DOCUMENT TYPE: Journal CA Section: 63 (Pharmaceuticals) The dissoln. kinetics of RJ-64 (I) [27199-40-2]; drotaverin [14009-24-6]; prenylamine [390-64-7]; carbutamide [339-43-5]; and acetazolamide [59-66-5] in H2O solns., and in aq. solns. of surfactants (Tween 20 [9005-64-5]; polyoxyethylene sorbitan monolaurate [9005-64-5]) are described. In all solns., the satn. process was kinetically excellent. For drotaverin and I, the amts. of the dissolving substance decreased in equal proportions with the surfactant concns. in contrast to results obsd. with the rest of the tested drugs.