Detail of "39028-27-8"

Reference

Preparation and blood clearance kinetics of galactosyl-contg

Preparation and blood clearance kinetics of galactosyl-contg. avidin and streptavidin compounds. Rosebrough, Scott F. (Rosebrough, Scott F., USA). PCT Int. Appl. WO 9640761 A1 19 Dec 1996, 128 pp. DESIGNATED STATES: W: AL, AM, AT, AU, AZ, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IL, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LS, LT, LU, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, NL, PT, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07K014-00. ICS: C07K014-195. APPLICATION: WO 1996-US9845 7 Jun 1996. PRIORITY: US 1995-484139 7 Jun 1995. DOCUMENT TYPE: Patent CA Section: 33 (Carbohydrates) Section cross-reference(s): 6, 15, 34 The present invention provides modified avidin and streptavidin (SA) compds. {[XO(CH2)p]C(R4)bCH2MCH2C(O)NH}nSA (X = sugar ester; R4 = H, alkyl; M = bond, alkylene, arylalkylene, ; p = 1-20; b= 0-2; n = 1-20; SA = streptavidin) that have suitable blood clearance kinetics for use in a two-step approach to deliver a mol.There are some commonly used reagents with their cas registry numbers 131968-68-8 and 39028-27-8 in this article. to a target site. In particular, to hasten SA's blood clearance carbohydrate moieties are covalently bonded to SA. To prolong avidin's blood clearance, avidin is deglycosylated and/or neutralized by alkylation of its lysine amino acids. In a two-step approach, biotinylated compds. are used to deliver radionuclides, cytotoxic drugs, MRI agents, fluorochromes and other agents suitable for imaging and therapy to target-bound modified streptavidin or avidin conjugated antibodies or other targeting agents. .

Polypeptide-dendrimer complexes

Polypeptide-dendrimer complexes. Singh, Pratap (Dade International Inc., USA). PCT Int. Appl. WO 9707398 A1 27 Feb 1997, 64 pp. DESIGNATED STATES: W: AU, CA, JP; RW: AT, BE, CH, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: G01N033-545. ICS: G01N033-535. APPLICATION: WO 1996-US13057 9 Aug 1996. PRIORITY: US 1995-514075 11 Aug 1995. DOCUMENT TYPE: Patent CA Section: 9 (Biochemical Methods) Section cross-reference(s): 2, 7, 15, 34 Compns. are disclosed, comprising dendrimers to which a first polypeptide is controllably coupled. Such polypeptide-dendrimer compns. are effective for controllably coupling a second polypeptide to the dendrimer. The first and second polypeptides have sep. and distinct defined biol. activities, for example, two antibodies with first and second binding specificities or an antibody and an enzymic label. Such compns. are useful as indicators in specific binding assays, e.g., immunoassays. Methods for sequentially coupling two different polypeptides to a dendrimer to form compns. of the invention also are disclosed. The protein-dendrimer complexes can be used as indicators in the detn. of, e.g., creatine kinase MB, peptide hormones, etc.Except for chemicals metioned above, 39028-27-8 and 51857-17-1 are also used. .