Detail of "39219-64-2"

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Subacute toxicity of ethylenebis(isothiocyanate) sulfide in the laboratory rat

Subacute toxicity of ethylenebis(isothiocyanate) sulfide in the laboratory rat. Freudenthal, Ralph I.; Kerchner, Gail A. 39219-64-2 which is the cas registry number of some chemical is mentioned.; Persing, Ronald L.; Baumel, Irwin; Baron, Ronald L. (Battelle Columbus Lab., Columbus, Ohio, USA). J. Toxicol. Environ. Health, 2(5), 1067-78 (English) 1977. CODEN: JTEHD6. DOCUMENT TYPE: Journal CA Section: 4 (Toxicology) Ethylenebisisothiocyanate sulfide (EBIS) [39219-64-2] was administered in the diet to rats at 0, 1, 10, 100, and 1000 ppm for up to 90 days. Only rats receiving EBIS at 1000 ppm demonstrated a toxic response within 8-14 days, reflected as a reversible paralysis of the hind legs. If left on the 1000 ppm diet, the animals soon died. When removed from the diet, the animals recovered, only to become ataxic on further dietary exposure at the high level. No histol. lesion could be identified in brain, spinal cord, or peripheral nerves from the paralyzed animals. The ability to reverse the paralysis by removing the animals from the test diet coupled with the lack of histol. observable lesions suggests a biochem. (reversible) rather than somatic lesion. Ingestiin of 1000 ppm EBIS for 7 days resulted in measurable changes in thyroid function. Total serum thyroxine levels were markedly decreased, as was iodide uptake by the thyroid. .