39465-37-7

 The crude venom of T. serrulatus contains different toxins. Some of the strongest derivates are the neurotoxins tityustoxin and toxin Ts-g (Clemente, Rossoni et al. 1999). Two types of toxins are considered to be responsible for the main toxic effect: toxin gamma (an α-type toxin) and tityustoxin (TsTX, a β-type toxin), both with a specific affinity to the sodium channel. (Mesquita, Moraes-Santos et al. 2003) Other types of venom are: TsTX-kα, an 37 amino acid (Werkman, Gustafson et al. 1993), toxin gamma (TsTX-γ and TsTX-I) with 61 amino acid residues is the major neurotoxin of this venom. TsTX-Kβ has a longer chain. (Novello, Arantes et al. 1999) K+ channels blocking peptides are single chain polypeptides of 30-40 amino acids with three sulfide bridges (Legros, Oughuideni et al. 1996). The toxin with four disulfide bonds is from TsTX-IV. This contains 41 amino acid residues.
Product Name: Tityustoxin
Synonyms of Tityustoxin (CAS NO.39465-37-7): Tityustoxin ka ; Tityustoxin k-alpha ; Tstx-ka ; Tstx-k-alpha ; Val-phe-ile-asn-ala-lys-cys-arg-gly-ser-pro-glu-cys-leu-pro-lys-cys-lys-glu-ala-ile-gly-lys-ala-ala-gly-lys-cys-met-asn-gly-lys-cys-lys-cys-tyr-pro
Product Categories: Monovalent Ion Channels;Toxins and Venoms;Voltage-gated Ion Channels
Storage temp: -20 °C
Solubility in water: soluble
Apperance: lyophilized powder

Scorpions are distributed among six families. Only those of the Buthidae family are dangerous to humans. Within this family, the Tityinae subfamily cause the most scorpion poisoning in humans. (Correa, Sampaio et al. 1997). These species are found in Brazil (Tityus serrulatus, T. bahiensis and T. stigmurus) and in Northern and Southern Venezuela (T. discrepans) (Novello, Arantes et al. 1999). The venom of Tityus Serrulatus is the most potent of these (Correa, Sampaio et al. 1997).

The lung edema induced by TsTX(CAS NO.39465-37-7) is blocked by 170 mg/kg of phenobarbital.Rabbit anti-TsNTxP antibodies displayed cross-reactivity with the scorpion toxins and showed in vitro neutralizing capacity. Thus, this protein emerges as a strong candidate for the production of antiserum to be used in the treatment of scorpion stings. The nontoxic recombinant protein can induce a level of circulating antibodies sufficient to neutralize the toxic effects of Tityus toxins and is a good candidate for use in the production of a new generation of neutralizing polyclonal antibodies for clinical use.

The venom of Tityus serrulatus is the most potent of the toxins from the species (Clemente, Rossoni et al. 1999). Tityustoxin-1, TsTX-I is the most toxic protein among the neurotoxins in this venom, with an intravenous and intracisternal LD50 (mouse) of 76 k 9 and 1.1 + 0.3 /lg/kg, respectively. The identification of TsTX-I as a potent component of T. serrulatus venom characterized it as the major and main neurotoxin from this venom (Correa, Sampaio et al. 1997). Poisoning effects in man evoked by T. serrulatus venom are sialorrhea, lacrimation and rhinorrhea. (Clemente, Rossoni et al. 1999) and acute pancreatitis (Correa, Sampaio et al. 1997). Catecholamines by the adrenal glands and postganglionic nerve terminals and Ach by ganglions and postganglionic nerve terminals are released when the poison strikes. Also other neurotransmitters are released by the whole venom and isolated toxins (Correa, Sampaio et al. 1997). In rats, the Tityustoxin caused dramatic effects on the circulatory and respiratory systems, consisting of hypotension, tachypnea, hyperpnea, ataxic and gasping breathing. Following these initial effects, 5 or 10 pg of TsTX induced hypertension and hyperpnea. The largest dose produced apnea and death about 70 min later (Lima and Freire-Maia 1977).

A poison by intraperitoneal route. Moderately toxic by intravenous route. When heated to decomposition it emits acrid smoke and irritating vapors.Safety information of Tityustoxin (CAS NO.39465-37-7):
WGK Germany:  3
RTECS:  XR3030000

 Tityustoxin is a toxin found in the venom of scorpions from the family of Tityinae. By binding to voltage-dependent sodium ion channels and potassium channels, they cause sialorrhea, lacrimation and rhinorrhea.