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Synthesis and spectral characterization of a novel fluorescent functional monomer 2,4-dimethyl-7-acrylamine-1,8-naphthyridine

All Rights Reserved. Synthesis and spectral characterization of a novel fluorescent functional monomer 2,4-dimethyl-7-acrylamine-1,8-naphthyridine. Zhou, Yan-mei; Xu, Wen-guo; Tong, Ai-jun; Tong, Chun-yuan (School of Science, Beijing Institute of Technology, Beijing 100081, Peop. Rep. China). Guangpuxue Yu Guangpu Fenxi, 26(3), 496-498 (Chinese) 2006 Beijing Daxue Chubanshe. CODEN: GYGFED. ISSN: 1000-0593. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) A new fluorescent functional monomer 2,4-dimethyl-7-acrylamine-1,8-naphthyridine (DMAAN) has been designed and synthesized for the first time. The monomer was expected to bind with cytosine via complementary hydrogen bonding under certain exptl. conditions. The synthetic procedure of DMAAN is as follows. A suspension of 2,6-diaminopyridine in phosphoric acid was added to acetylacetone. The mixt. was warmed for thirty minutes on a steam-bath. Then 2,4-dimethyl-7-amino-1,8-naphthyridine (DMAN, mp 216-218°) was obtained. DMAAN was prepd. by the reaction of DMAN with acryloyl chloride in chloroform and tri-Et ether mixed solvent. Acryloyl chloride in anhyd. chloroform was added dropwise over 30 min with const. stirring at 4°. The m.p. of the final product was 239-241°. Mass spectrometry and proton NMR were used to confirm the chem. 39565-07-6 and 123-54-6 are just another two chemicals used in this study. structure of DMAN and DMAAN. The products were also characterized by UV and fluorescence spectrometry. .