Detail of "3964-52-1"

Reference

Solid phase synthesis of arylretinamides for their therapeutic use as anticancer agents

Solid phase synthesis of arylretinamides for their therapeutic use as anticancer agents. Curley, Robert W., Jr.; Mershon, Serena M.; Barnett, Derek W.; Clagett-Dame, Margaret; Chapman, Jason S. (The Ohio State University Research Foundation, USA). PCT Int. Appl. WO 2003003987 A2 16 Jan 2003, 51 pp.In this article, certain chemicals are used. One of their cas registry numbers is 20638-84-0 DESIGNATED STATES: W: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NO, NZ, OM, PH, PL, PT, RO, RU, SD, SE, SG, SI, SK, SL, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VN, YU, ZA, ZM, ZW, AM, AZ, BY, KG, KZ, MD, RU, TJ, TM; RW: AT, BE, BF, BJ, CF, CG, CH, CI, CM, CY, DE, DK, ES, FI, FR, GA, GB, GR, IE, IT, LU, MC, ML, MR, NE, NL, PT, SE, SN, TD, TG, TR. (English). (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: A61K. APPLICATION: WO 2002-US21452 8 Jul 2002. PRIORITY: US 2001-PV303616 6 Jul 2001. DOCUMENT TYPE: Patent CA Section: 30 (Terpenes and Terpenoids) Section cross-reference(s): 1, 63 The present invention discloses a solid phase synthetic method for prepg. arylretinamides, such as I [R2 = H, OH, NO2, CH2OH, halide, alkyl; R3 = H, OH, NO2, carboxyalkyl, halide, alkyl; R4 = H, OH, alkyloxy, alkylsulfonyl, NH2, acylamino, N3, halide, alkyl; R5 = H, NO2, alkyl, carboxyalkyl, halide; R6 = H, CO2H, carboxyalkyl, halide, alkyl; R7 = H, alkyl], for their therapeutic use as anticancer agents. The method comprises reacting hexachloroacetone with a solvent-suspended resin-bound triphenylphosphine to provide a suspension comprising an activated chlorinating reagent; reacting retinoic acid with the activated chlorinating reagent to provide retinoyl chloride; adding pyridine and a select arylamine to the resulting mixt.; and stirring the resulting mixt.There are some commonly used reagents with their cas registry numbers 3964-52-1 and 65-49-6 in this article. for a time and at a temp. sufficient for the select arylamine to react with the retinoyl chloride and provide the arylretinamide. The prepd. arylretinamide derivs. were tested for inhibition of growth of cultured MCF-7 cells. Also provided, are methods of using I to induce apoptosis in cancer cells. ..