Reference

Sedation and the stimulus properties of antihistamines

Sedation and the stimulus properties of antihistamines. Winter, J. C. (Dep. Pharmacol. Ther., State Univ. New York, Buffalo, NY 14214, USA). Pharmacol., Biochem. Behav., 22(1), 15-17 (English) 1985. CODEN: PBBHAU. ISSN: 0091-3057. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A group of 6 rats was trained to discriminate the effects of diphenhydramine [58-73-1] (10 mg/kg; 30 min pretreatment time) and saline in a 2-lever choice task, using a fixed ratio schedule of water reinforcement. Stimulus control was assumed to be present when 80% or more of the 1st 10 responses were appropriate for the treatment condition on each of 5 consecutive days. Diphenhydramine established stimulus control in each of the animals. The mean no. of sessions prior to the onset of criterion performance was 26. A 2nd group of 6 rats was similarly trained with chlorpheniramine maleate [113-92-8] (10 mg/kg; 30 min pretreatment time) and saline. Four of the group reached criterion performance in a mean of 56 sessions. The diphenhydramine stimulus generalized completely to promethazine [60-87-7], azatadine maleate [3978-86-7], and chlorpheniramine. In rats trained with chlorpheniramine, only promethazine and azatadine maleate substituted completely, while diphenhydramine yielded intermediate results, i.e., significantly different from both training conditions. Thus, the relative propensity of antihistamines to induce sedation in humans is not correlated with distinctive stimulus properties in the rat.

Treatment of autologous immune complex glomerulonephritis with vasoactive amine antagonists

Treatment of autologous immune complex glomerulonephritis with vasoactive amine antagonists. Garovoy, Marvin R.; Kupor, Lary R.; Mullins, James D.; McPhaul, John J., Jr. (Dep. Med., Peter Bent Brigham Hosp., Boston, Mass., USA). J. Lab. Clin. Med., 90(4), 638-44 (English) 1977. CODEN: JLCMAK. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Section cross-reference(s): 15 The vasoactive amine antagonists Chlortrimeton [113-92-8], Vistaril [10246-75-0], Azatadine maleate [3978-86-7], and Sansert [129-49-7], when given singly or in combinations which completely abrogated histamine and serotonin-induced skin wheal formation, were unsuccessful at reducing apparent glomerular deposition of the circulating immune complexes of AIC nephritis.