CAS No.39831-55-5,Amikacin disulfate salt Suppliers

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Basic Information

Molecular Structure:
CAS No.:	39831-55-5
Name:	Amikacin disulfate salt

Formula:	C₂₂H₄₃N₅O₁₃^.2(H₂SO₄)
Molecular Weight:	781.768
Synonyms:	Amikacin disulfate salt;4)]-N1-[(2S)-4-amino-2-hydroxy-1-oxobutyl]-2-deoxy-,sulfate (1:2) (salt) (9CI);Amiglyde V;Amika;Amikacin disulfate;Amikacinsulfate;Amikavet;Amikin;Amiklin;Antibiotic BB-K 8 sulfate;Biklin;Biodacyn;Fabianol;Grasil;Kaminax;Mikavir;Pierami;
EINECS:	254-648-6
Melting Point:	220-230 °C
Boiling Point:	981.8 °C at 760 mmHg
Flash Point:	547.6 °C
Solubility:	H₂O: 50 mg/mL, clear, colorless
Appearance:	white
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	497.90000
LogP:	-4.37610

Synthetic route

: 37517-28-5
amikacin

: 39831-55-5
amikacin sulfate

Conditions

Conditions	Yield
With sulfuric acid In ethanol; water at 10℃; for 6h; Temperature;	91.5%

: 39831-55-5
amikacin sulfate

: 1448168-07-7
3-C-azido amikacin

Conditions

Conditions	Yield
With imidazole-1-sulfonyl azide hydrochloride In water at 20℃; for 40h; pH=7; regioselective reaction;	29%

: 39831-55-5
amikacin sulfate

: 37517-28-5
amikacin

Conditions

Conditions	Yield
With Amberlite ion exchange resin (OH-form) In water for 1h;

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Chemistry

Molecular Structure of Antibiotic bb-k8 sulfate (CAS NO.39831-55-5):

IUPAC Name: (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-[(2S,3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-4-[(2R,3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxyoxan-2-yl]oxy-3-hydroxycyclohexyl]-2-hydroxybutanamide
Product Name: Amikacin disulfate salt
Molecular formula: C₂₂H₄₇N₅O₂₁S₂
Molecular Weight: 781.76
EINECS: 254-648-6
Melting point:220-230 °C
Flash Point: 547.6 °C
Enthalpy of Vaporization: 162.21 kJ/mol
Boiling Point: 981.8 °C at 760 mmHg
Vapour Pressure: 0 mmHg at 25°C
Storage temp: 2-8°C
Solubility: H₂O: 50 mg/mL
InChI
InChI=1/C22H43N5O13.2H2O4S/c23-2-1-8(29)20(36)27-7-3-6(25)18(39-22-16(34)15(33)13(31)9(4-24)37-22)17(35)19(7)40-21-14(32)11(26)12(30)10(5-28)38-21;2*1-5(2,3)4/h6-19,21-22,28-35H,1-5,23-26H2,(H,27,36);2*(H2,1,2,3,4)/t6-,7+,8-,9+,10+,11-,12+,13+,14+,15-,16+,17-,18+,19-,21+,22+;;/m0../s1
Smiles
O([C@H]1[C@@H](C[C@@H]([C@H]([C@@H]1O)O[C@H]1O[C@@H]([C@@H](O)[C@@H]([C@H]1O)O)CN)N)NC([C@H](CCN)O)=O)[C@H]1O[C@@H]([C@@H](O)[C@@H]([C@H]1O)N)CO.S(O)(O)(=O)=O.S(O)(O)(=O)=O
Product Categories: Active Pharmaceutical Ingredients

Toxicity Data With Reference

Organism	Test Type	Route	Reported Dose (Normalized Dose)	Effect	Source
dog	LD50	intramuscular	> 667mg/kg (667mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977.
dog	LD50	intravenous	383mg/kg (383mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977.
monkey	LD50	intramuscular	> 1335mg/kg (1335mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977.
mouse	LD50	intramuscular	1247mg/kg (1247mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse	LD50	intraperitoneal	2930mg/kg (2930mg/kg)		Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
mouse	LD50	intravenous	181mg/kg (181mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) LUNGS, THORAX, OR RESPIRATION: DYSPNEA BEHAVIORAL: ATAXIA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
mouse	LD50	oral	> 10679mg/kg (10679mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977.
mouse	LD50	subcutaneous	2470mg/kg (2470mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977.
rabbit	LD50	intramuscular	> 3gm/kg (3000mg/kg)		Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rabbit	LD50	intravenous	248mg/kg (248mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977.
rabbit	LD50	oral	> 3gm/kg (3000mg/kg)		Drugs in Japan Vol. -, Pg. 45, 1990.
rat	LD50	intramuscular	2244mg/kg (2244mg/kg)	BEHAVIORAL: SOMNOLENCE (GENERAL DEPRESSED ACTIVITY) BEHAVIORAL: ATAXIA LUNGS, THORAX, OR RESPIRATION: DYSPNEA	Japanese Journal of Antibiotics. Vol. 39, Pg. 3164, 1986.
rat	LD50	intraperitoneal	3500mg/kg (3500mg/kg)		Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rat	LD50	intravenous	234mg/kg (234mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977.
rat	LD50	oral	> 4gm/kg (4000mg/kg)		Japanese Journal of Antibiotics. Vol. 28, Pg. 415, 1975.
rat	LD50	subcutaneous	3604mg/kg (3604mg/kg)		Pharmacological and Biochemical Properties of Drug Substances. Vol. 1, Pg. 125, 1977.

Safety Profile

Poison by intravenous route. Moderately toxic by intraperitoneal and subcutaneous routes. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits very toxic fumes of NO_x and SO_x. See also sulfates.
Hazard Codes: Irritant Xi
The Risk Statements information of Antibiotic bb-k8 sulfate (CAS NO.39831-55-5):
36/37/38: Irritating to eyes, respiratory system and skin
The Safety Statements information of Antibiotic bb-k8 sulfate (CAS NO.39831-55-5) :
26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice
36: Wear suitable protective clothing
WGK Germany: 2
RTECS: WK1961200
F: 3-10

Specification

Antibiotic bb-k8 sulfate , with CAS number of 39831-55-5, can be called (2S)-4-amino-N-[(1R,2S,3S,4R,5S)-5-amino-2-(3-amino-3-deoxy-alpha-D-glucopyranosyloxy)-4-(6-amino-6-deoxy-alpha-D-glucopyranosyloxy)-3-hydroxycyclohexyl]-2-hydroxybutanamide disulfate ; (R)-4-amino-N-((1R,2R,3S,4R,5S)-5-amino-2-((3R,4S,5S,6R)-4-amino-3,5-dihydroxy-6-(hydroxymethyl)-tetrahydro-2H-pyran-2-yloxy)-4-((3R,4S,5S,6R)-6-(aminomethyl)-3,4,5-trihydroxy-tetrahydro-2H-pyran-2-yloxy)-3-hydroxycyclohexyl)-2-hydroxybutanamide ; amikacin bis(sulphate) ; Amikacin disulfate salt .

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