Detail of "40059-53-8"

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Reactions of 2-methyl-3,1-benzoxazin-4-one with active methylene compounds: a new route to 3-substituted 4-hydroxyquinolin-2-(1H)-ones

Reactions of 2-methyl-3,1-benzoxazin-4-one with active methylene compounds: a new route to 3-substituted 4-hydroxyquinolin-2-(1H)-ones. Detsi, Anastasia; Bardakos, Vassilios; Markopoulos, John; Igglessi-Markopoulou, Alga (Lab. Org. Chem., Univ. Athens, Athens 157 73, Greece). Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry, (24), 2909-2913 (English) 1996 Royal Society of Chemistry. CODEN: JCPRB4. ISSN: 0300-922X. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) A new route to 3-substituted 4-hydroxyquinolin-2(1H)-ones I (Y = cyano, CO2Me, CO2Et, COMe, SO2Me), compds. of great biol. importance, is described. The C-acylation of active methylene compds. YCH2Z with 2-methyl-3,1-benzoxazin-4-one, under basic conditions, leads to the formation of the new products 2-(MeCONH)C6H4C(OH):CYZ, which have been isolated and characterized. Cyclization of the above intermediates furnishes the 3-substituted 4-hydroxyquinolin-2(1H)-ones I.There are some commonly used reagents with their cas registry numbers 40059-53-8 and 186609-91-6 in this article. Spectral data and phys. characteristics for all compds. are reported. .

The reaction of 1R-3-bromo-3-alkyl(carbethoxy)-2,4-dioxoquinolines with hydrazine hydrate

The reaction of 1R-3-bromo-3-alkyl(carbethoxy)-2,4-dioxoquinolines with hydrazine hydrate. Ukrainets, I. V.; Prokopenko, O. S.; Sidorenko, L. V.; Gorokhova, O. V. (Nats. 40059-53-8 which is the cas registry number of one of substances is just one of reagents here. Far. 40059-53-8 which is the cas registry number is also used here. Univ., Ukraine). Farmatsevtichnii Zhurnal (Kiev), (3), 70-77 (Ukrainian) 2004 Zdorov'ya. CODEN: FRZKAP. ISSN: 0367-3057. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 75 3-Bromo-substituted quinoline-2,4-diones I (R1 = H, R2 = Me, Et, n-Pr, PhCH2; R1 = H, Me, Et, n-Pr, R2 = EtO2C) react easily with hydrazine hydrate to give 4-hydroxy-2-quinolones II in high yields. The structure of II (R1 = H; R2 = EtO2C) was confirmed by X-ray diffraction anal. During the process, hydrazine hydrate is oxidized to the corresponding diimide which was indirectly detd. by 1H NMR spectroscopy and chromato-mass spectrometry. ..