Reference

Nonsteroidal antiinflammatory drugs which exert an inhibitory effect on mitochondrial reactions

Nonsteroidal antiinflammatory drugs which exert an inhibitory effect on mitochondrial reactions. Shiojiri, Hiroshi; Kawai, K.; Nozawa, Y.; Nozaki, M.; Tsurumi, K.; Fujimura, H. (Tsukuba Res. Lab., Eisai Co. Ltd., Tsukuba 300-26, Japan). Drugs Exp. Clin. Res., 10(12), 857-62 (English) 1984. CODEN: DECRDP. ISSN: 0378-6501. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) In isolated rat liver mitochondria, indomethacin [53-86-1] uncoupled oxidative phosphorylation and depressed state 3 respiration. However, a farnesyl ester of indomethacin E-0710 [70896-44-5], exhibited neither uncoupling nor inhibitory effects on mitochondrial respiration. Clidanac [34148-01-1], benoxaprofen [51234-28-7], GP-53633 [40061-07-2], and tioxaprofen [40198-53-6] also uncoupled oxidative phosphorylation. The uncoupling effect of clidanac and tioxaprofen was far stronger than that of indomethacin. The uncoupling effects of these compds. were characterized by a secondary effect due to a marked suppression of state 3 respiration.

Human pharmacological investigations on the platelet adhesiveness- and aggregation-inhibiting effect of EMD 26 644, an oxazolyl-thio-propionic acid derivative

Human pharmacological investigations on the platelet adhesiveness- and aggregation-inhibiting effect of EMD 26 644, an oxazolyl-thio-propionic acid derivative. Jacobi, E.; Leopold, G.; Lissner, R.; Maisenbacher, J. (2nd Med. Clin. Policlin., Univ. Duesseldorf, Duesseldorf, Ger.). Int. J. Clin. Pharmacol. Biopharm., 16(3), 136-41 (English) 1978. CODEN: IJCBDX. ISSN: 0340-0026. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) EMD 26644 (I) [40198-53-6] (250 mg, orally) given to volunteers inhibited the platelet aggregation and adhesiveness for several days.