Detail of "40216-82-8"

CAS Number:
40216-82-8
Name:
L-Ornithine, methyl ester, hydrochloride (1:2)
Superlist Name:
Methyl L-ornithine dihydrochloride
Molecular Structure:
Formula:
C₆H₁₆Cl₂N₂O₂
Molecular Weight:
219.11
Synonyms:
L-Ornithine, methyl ester, dihydrochloride(9CI);Ornithine, methyl ester, dihydrochloride,L- (7CI);H-Orn-Ome·2HCl;H-Orn-OMec2HCl;
EINECS:
254-841-5
Boiling Point:
300.9 °C at 760 mmHg
Flash Point:
135.8 °C

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Convenient process of manufacture for difluoromethylornithine and related compounds via fluoroalkylation of protected ornithine esters: Convenient process of manufacture for difluoromethylornithine and related compounds via fluoroalkylation of protected ornithine esters. Majeed, Muhammed; Nagabhushanam, Kalyanam; Rapole, Keshava Rao; Chebolu, Ravikrishna (Sabinsa Corporation, USA). U.S. US 6998502 B1 14 Feb 2006, 5 pp. (English). (United States of America). CODEN: USXXAM. APPLICATION: US 2002-236992 5 Sep 2002. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) A process for the manuf. of a-difluoromethylornithine analogs and derivs. I (R2 = OH, C1-8 alkoxy, NR'R"; R', R" = independently H, C1-8 alkyl; R4 = CH2F, CHF2, CF3) is described from ornithine hydrochloride or from Nd-phthaloylornithine hydrochloride, conversion to an alkyl ester, conversion to solid derivs. through the formation of Schiff bases, subsequent halomethylation using suitable bases and hydrolysis. 40216-82-8 are also occured in this study. Thus, Schiff base II (prepd. in 2 steps from L-ornithine monohydrochloride) was deprotonated with lithium hexamethyldisilazane in THF, treated with chlorodifluoromethane at 5-10°, and hydrolyzed with HCl to give eflornithine hydrochloride (I; R2 = OH, R4 = CHF2). .Except for chemicals metioned above, 40216-82-8 is also used..

Convenient process of manufacture for difluoromethylornithine and related compounds via fluoroalkylation of protected ornithine esters: Convenient process of manufacture for difluoromethylornithine and related compounds via fluoroalkylation of protected ornithine esters. Majeed, Muhammed; Nagabhushanam, Kalyanam; Rapole, Keshava Rao; Chebolu, Ravikrishna (Sabinsa Corporation, USA). U.S. US 6998502 B1 14 Feb 2006, 5 pp. (English). (United States of America). CODEN: USXXAM. APPLICATION: US 2002-236992 5 Sep 2002. DOCUMENT TYPE: Patent CA Section: 34 (Amino Acids, Peptides, and Proteins) A process for the manuf. of a-difluoromethylornithine analogs and derivs. I (R2 = OH, C1-8 alkoxy, NR'R"; R', R" = independently H, C1-8 alkyl; R4 = CH2F, CHF2, CF3) is described from ornithine hydrochloride or from Nd-phthaloylornithine hydrochloride, conversion to an alkyl ester, conversion to solid derivs. through the formation of Schiff bases, subsequent halomethylation using suitable bases and hydrolysis. 40216-82-8 are also occured in this study. Thus, Schiff base II (prepd. in 2 steps from L-ornithine monohydrochloride) was deprotonated with lithium hexamethyldisilazane in THF, treated with chlorodifluoromethane at 5-10°, and hydrolyzed with HCl to give eflornithine hydrochloride (I; R2 = OH, R4 = CHF2). .Except for chemicals metioned above, 40216-82-8 is also used..