Reference

Research on tumor inhibiting compounds

Research on tumor inhibiting compounds. Part LVII. Nucleophilic aromatic substitution in 1-nitro-7-bromo-9-acridone and other bromoacridones. Ledochowski, Andrzej; Skonieczny, Stanislaw; Glowacki, Andrzej; Mogielnicki, Jerzy (Inst. Org. Food Chem. Technol., Polytech. Univ., Gdansk, Pol.). Rocz. Chem., 51(2), 357-64 (English) 1977. 40239-75-6 is the cas registry number of certain chemical which is used as reagents here. CODEN: ROCHAC. 27693-70-5 is the cas registry number of certain chemical which is used as reagents here. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Bromination of 1-nitro-9-acridone (I) gave the 7-bromo deriv. (II) which reacted with NH2Na to give a mixt. of 1-nitro-6-, 7-, and 8-amino-9-acridones. II reacted with MeOK to give I. 3-Bromo-9-acridone with K phthalimide gave 3-phthalimido-9-acridone (III) in 82% yield. III was reduced in pyridine with H2NNH2.H2O to 3-amino-9-acridone. Similarly other amino derivs. were obtained. ..