Reference

Bioavailable crystalline form of cefuroxime axetil

Bioavailable crystalline form of cefuroxime axetil. Zenoni, Maurizio; Leone, Mario; Cattaneo, Angelo; Marsili, Leonardo ( Acs Dobfar S.P.A., Italy). Eur. Pat. Appl. EP 757991 A1 12 Feb 1997, 13 pp. DESIGNATED STATES: R: AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LI, LU, NL, PT, SE. (English). (European Patent Organization). CODEN: EPXXDW. CLASS: ICM: C07D501-34. ICS: A61K031-545. APPLICATION: EP 1996-109665 17 Jun 1996. PRIORITY: IT 1995-MI1716 3 Aug 1995. 40258-78-4 and 506-96-7 which are cas registry numbers are also used here. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 26 A bioavailable cryst. form of cefuroxime axetil (I), obtained by treating known cryst. or amorphous I with water or with a water-miscible org. solvent or with a mixt. thereof at a temp. of between +20°C and +100°C, followed by cooling and sepg. the cryst. product by known methods. Thus, 5 g amorphous I (prepn. given) was treated with 50 mL water at 40° for 3 h, then it was cooled to ambient temp. and filtered. The dried product (4.8 g) had an R/S ratio of 0.64, and IR spectrum similar to b crystals. .