Detail of "40276-11-7"

Reference

Styrene derivatives as tyrosine kinase inhibitors in cancer therapy

Styrene derivatives as tyrosine kinase inhibitors in cancer therapy. Shiraishi, Tadayoshi; Domoto, Takashi; Imai, Naohiro; Katsumi, Ikuo; Watanabe, Kiyoshi (Kanegafuchi Chemical Industry Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 62042923 A2 24 Feb 1987 Showa, 5 pp. (Japan) CODEN: JKXXAF. CLASS: ICM: A61K031-04. ICS: A61K031-05; A61K031-085; A61K031-365; A61K031-415; C07C079-10; C07C079-35; C07C127-22; C12N009-99. ICA: C07D233-96; C07D307-58. 40276-11-7 and 108303-13-5 which are cas registry numbers are also used here. APPLICATION: JP 85-182637 19 Aug 1985. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Antitumor formulations contain tyrosine kinase inhibitors, styrene derivs. (I; R1, R2 = H, OH, C1-4 alkoxy, phenoxy; R3 = NO2; R4 = H, R3R4 = CO2CH2CH2 or CONHCONH. 2,5-Dimethoxy-b-nitrostyrene (II) 100, lactose 55, and potato starch 41 g were mixed with 20 mL H2O, and the mixt. was granulated (16 mesh), combined with 4 g Mg stearate, and made into tablets (200 mg/tablet). II was prepd. by treating 2,5-dimethoxybenzaldehyde with CH3NO2 in benzene contg. piperidine and AcOH. .