Reference

Preparation of imidazolylbenzoylheterocycles as class III antiarrhythmics

Preparation of imidazolylbenzoylheterocycles as class III antiarrhythmics. Chou, You Ling; Erhardt, Paul William; Hagedorn, Alfred Arthur; Lampe, John W.; Lumma, William Carl, Jr.; Morgan, Thomas Kenneth; Wiggins, Jay Ross (Schering A.-G., Germany).Chemicals with cas numbers 593-51-1 and 403-43-0 also play role. PCT Int. Appl. WO 9119709 A1 26 Dec 1991, 50 pp. DESIGNATED STATES: W: JP; RW: AT, BE, CH, DE, DK, ES, FR, GB, GR, IT, LU, NL, SE. (World Intellectual Property Organization). CODEN: PIXXD2. CLASS: ICM: C07D401-10. ICS: C07D401-12; C07D403-10; A61K031-445; A61K031-495. APPLICATION: WO 91-EP1137 19 Jun 1991. PRIORITY: US 90-540980 20 Jun 1990. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Title compds. [I; A = Q1-Q3; Y = NR1C(:W)NR2R3, NR1CO2R3, CONR2R3, COR3, NR1COR3, CO2R3, etc.; W = O, S, NR, NCN, CHNO2; Z = COR3; R = alkyl, (substituted) aryl, arylalkyl; R1, R2, R4 = H, alkyl; R3 = alkyl, (substituted) aryl, arylalkyl, heteroaryl; n = 0-2], were prepd. as class III antiarrhythmics (no data). Thus, N-[1-(4-fluorobenzoyl)-4-piperidinyl]hexanamide, imidazole, and K2CO3 were heated 42 h in DMSO at 130° to give title compd. II. .

Synthesis and Evaluation of Novel Ferrocenyl Thiazole Derivatives as Anticancer Agents

Shao, Ling; Zhou, Xin; Hu, Yan; Jin, Zhong; Liu, Jianbing; Fang, Jian-xin (State Key Laboratory of Elemento-Organic Chemistry, Institute of Elemento-Organic Chemistry, Nankai University, Tianjin, Peop. Rep. China). Synthesis and Reactivity in Inorganic, Metal-Organic, and Nano-Metal Chemistry, 36(4), 325-330 (English) 2006 Taylor & Francis, Inc. CODEN: SRIMDO. ISSN: 1553-3174. DOCUMENT TYPE: Journal CA Section: 29 (Organometallic and Organometalloidal Compounds) Section cross-reference(s): 1, 28, 75 Novel ferrocenyl-contg. triazole-1-yl-1,3-thiazol-2-yl benzamide derivs.Several reagents with their cas registry numbers 403-43-0 and 897943-34-9 are used here. were synthesized from 2-amino-4-ferrocenyl-5-(1H-1,2,4-triazole-1-yl)-1,3-thiazole and substituted benzoyl chlorides in CHCl3 contg. pyridine in 41-53% yields. The structures of these compds. were characterized by 1H NMR, elemental anal. and x-ray diffraction anal. Evaluation of anticancer activities showed that some of them possessed some degree of anticancer activity against human leukemia, gastric carcinoma and laryngeal carcinoma cell lines. There was a pronounced substituent effect on their biol. activity, with o- and m-methoxy-substituted benzamides and an unsubstituted dibenzoyl compd. showing the best activities. .