Reference

Preparation of iminothiazoles using no protective groups

All Rights Reserved. Preparation of iminothiazoles using no protective groups. Takahashi, Kazuhiko; Miyawaki, Takashi; Kanai, Toshio (Sumitomo Chemical Co., Ltd.; Dainippon Pharmaceutical Co., Ltd., Japan). Jpn. Kokai Tokkyo Koho JP 2007015999 A 25 Jan 2007, 15pp. (Japanese). (Japan). CODEN: JKXXAF. 921225-59-4 is the cas registry number of certain chemical which is used as reagents here. APPLICATION: JP 2005-201213 11 Jul 2005. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1 Title compds. I [R1, R2 = (un)substituted aryl] or their salts are prepd. by treatment of H2NCH2CH2NHCONHMe with R1NCS (R1 = same as above), followed by cyclocondensation of the resulting R1NHCSNHCH2CH2NHCONHMe with R2COCH2X (R2 = same as above; X = leaving group). The iminothiazoles are known as anti-inflammatory agents. Thus, ethylenediamine was treated with Ph N-methylcarbamate and 3-fluorophenyl isocyanate to give 85.5%, which was cyclocondensed with 2-bromo-1-(4-morpholin-4-ylphenyl)ethanone to afford I (R1 = 3-fluorophenyl, R2 = 4-morpholinophenyl) HBr salt. .

Derivatives and reactions of glutacondialdehyde

Derivatives and reactions of glutacondialdehyde. Part 3. 1-Aryl-3-formyl-2(1H)-pyridinethiones from the glutacondialdehyde anion and aryl isothiocyanates. Becher, Jan; Frandsen, Erik G. (Dep. Chem., Odense Univ., Odense, Den.). Acta Chem.Several substances with their cas registry numbers 61995-31-1 and 404-72-8 may be metioned in this study. Scand., Ser. B, B30(9), 863-6 (English) 1976. CODEN: ACBOCV. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) The 1-aryl-3-formyl-2(1H)-pyridinethiones I (R = Ph, 1-, 2-naphthyl, C6H5-nRn1, Rn1 = 3-Me, 3-F, 4-F, 2-CO2Me, 2,6-Me2, 2,6-Cl2) were prepd. from OCHCH2CH:CHCHO sodium salt and RNCS. The structure of I (R = Ph) was confirmed by conversion into II (Z = S, Z1 = H, OH, 1,3-dioxolan-2-yl; Z = Z1 =O). .