Detail of "404-82-0"

Reference

The sympathomimetic activity of fenfluramine hydrochloride on rat vas deferens

The sympathomimetic activity of fenfluramine hydrochloride on rat vas deferens. Mottram, D. R.; Wadhwani, D. (Dep. Pharmacol., Liverpool Polytech., Liverpool, Engl.). Br. J. Pharmacol., 59(4), 615-20 (English) 1977. CODEN: BJPCBM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In the rat isolated vas deferens, fenfluramine-HCl [404-82-0] (0.2mM) produced within 2-3 min spiked contractions at a rate of 13/min. Pretreatment with tyramine (0.4mM) greatly reduced the height and rate of fenfluramine-induced contractions. Desipramine (20 and 50.mu.M and 0.1mM but not <10.mu.M) treatment before or after fenfluramine reduced the height and rate of contractions. Debrisoquine (0.5mM) reduced, and reserpine (5 mg/kg) abolished, fenfluramine-induced contractions. Fenfluramine is thus a sympathomimetic compd. acting indirectly on peripheral adrenergic nerve terminals.

A comparative study of different amphetamines on copulatory behavior and stereotype activity in the female rat

A comparative study of different amphetamines on copulatory behavior and stereotype activity in the female rat. Michanek, Annika; Meyerson, Bengt J. (Dep. Med. Pharmacol., Univ. Uppsala, Uppsala, Swed.). Psychopharmacology (Berlin), 53(2), 175-83 (English) 1977. CODEN: PSCHDL. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) The influence of D- [51-63-8] and L-amphetamine sulfate [51-62-7] fenfluramine-HCl [404-82-0], and DL-p-chloroamphetamine [2275-84-5] on female copulatory behavior (lordosis response) and the induction of stereotype activity was compared. Lordosis response in the female rat has been shown to be inhibited by increased central nervous serotonergic (5-HT) as well as dopaminergic (DA) activity. A dose-dependent inhibitory effect on the estrogen- + progesterone-induced lordosis response in ovariectomized rats was demonstrated after treatment with the four amphetamines. In contrast, only D- and L-amphetamine induced a sterotype activity which is considered to be mediated by DA mechanisms. A decrease in DA receptor activity, achieved by pimozide pretreatment, abolished the effect of D-amphetamine on lordosis behavior, but the effect of L-amphetamine was only slightly diminished and the action of fenfluramine and p-chloroamphetamine was unaffected. On the other hand, both L- and D-amphetamine-induced stereotype activity was prevented by pimozide treatment. Thus, the D-amphetamine effect on lordosis behavior is mediated by increased DA receptor activity. Although it induces sterotype activity by increased DA activity, L-amphetamine, like fenfluramine and p-chloroamphetamine, inhibits the lordosis response by some other action presumably related to serotonergic mechanisms.