Detail of "4044-65-9"

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Effectiveness of jonit and ambilhar in experimental alveococcosis of white mice

Effectiveness of jonit and ambilhar in experimental alveococcosis of white mice. Chernyaeva, A. I.; Krotov, A. I. (Inst. Med. Parazitol. Trop. Med. im. Martsinovskogo, Moscow, USSR). Med. Parazitol. Parazit. Bolezni, 46(2), 224-5 (Russian) 1977. CODEN: MPPBAB. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) Jonit [4044-65-9], given at 5 mg/kg/day orally for 15 days to mice exptl. infected with Alveococcus multilocularis, inhibited by 45.5% the development of larvocysts, and similar dosing with ambilhar [61-57-4] at 25 mg/kg/day inhibited development by 55.6%. These drugs may be useful in worm therapy; esp. in combination with mebendazole and levamisole.

Surface characterization of indium-tin oxide thin electrode films for use as a conducting substrate in DNA sensor development

All Rights Reserved. Surface characterization of indium-tin oxide thin electrode films for use as a conducting substrate in DNA sensor development. Moore, E.; O'Connell, D.; Galvin, P. (Tyndall National Institute, University College Cork, Cork, Ire.). Thin Solid Films, 515(4), 2612-2617 (English) 2006 Elsevier B.V. CODEN: THSFAP. ISSN: 0040-6090. 4044-65-9 and 50926-11-9 are cas registry numbers. These chemicals are also mentioned in this article. DOCUMENT TYPE: Journal CA Section: 9 (Biochemical Methods) Section cross-reference(s): 66, 72 Indium tin oxide (ITO) films have over the past few years become a very important material for use as a conducting substrate in sensor development. Surface characterization with strict control of deposition and surface chem. of ITO films is essential for achieving reproducible conductive substrates. Usually a combination of different anal. techniques is used to monitor surface modification of these thin electrode films. ITO was deposited using an e-beam evaporator. SEM and At. Force Microscopy have been applied to examine surface topog. and det. surface roughness (0.5455 nm in root mean square, relative std. deviation 6%). The film is plasma treated in order to activate the surface further by creating a greater d. of hydroxyl groups. Silanization of the ITO surface using self-assembled monolayers is investigated with the aim of providing a platform for further covalent attachment chem. Quality control of the modified ITO films is verified based on sheet resistance (34 W/sq), % transmittance (> 90% at wavelength > 580 nm) and contact angle measurements. The optimum conditions reported in the prepn. of ITO thin films involved e-beam evapn. at a relatively slow rate and under relatively high pressure. Post annealing of the ITO film is detrimental to the surface uniformity Fourier Transform Infra-Red Spectroscopy and Cyclic Voltammetry are also described for anal. of the alkyl silane monolayers. Subsequent covalent attachment of a cross-linker and successful hybridization of Cy3 labeled 2-deoxy-5-RNA (DNA) to the immobilized complementary DNA clearly demonstrates that surface chem. modifications undertaken were successful. It also verified that ITO can be used as a substrate in the development of DNA sensors if the surface is firstly activated (plasma treatment) for attachment of surface chem. The development of such ITO based sensors has potential benefits as it can be used to bridge the gap between optical and electrochem. sensors, in that it offers the capability of dual detection, i.e. optical and elec. .