CAS No.40615-39-2,5'-O-Dimethoxytrityl-deoxythymidine Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	40615-39-2
Name:	5'-O-Dimethoxytrityl-deoxythymidine
Article Data:	163

Formula:	C₃₁H₃₂N₂O₇
Molecular Weight:	544.604
Synonyms:	Thymidine,5'-O-[a,a-bis(p-methoxyphenyl)benzyl]- (7CI);5'-O-(4,4'-Dimethoxytrityl)-2'-deoxythymidine;5'-O-(4,4'-Dimethoxytrityl)thymidine;5'-O-(Di-p-methoxytrityl)thymidine;5'-O-(p,p'-Dimethoxytrityl)thymidine;
EINECS:	255-003-1
Density:	1.272 g/cm³
Melting Point:	114-116 °C (subl.)(lit.)
Boiling Point:	618.41°C (rough estimate)
Solubility:	3mg/L at 20℃
Appearance:	White powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	26-36
PSA:	112.01000
LogP:	3.51930

Synthetic route

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 50-89-5
thymidine

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Conditions

Conditions	Yield
With pyridine; dmap at 20℃; for 5h;	97%
With pyridine; dmap at 20℃; for 24h;	96%
With pyridine at 20℃; for 12h;	96%

: 289712-59-0
2-Azidomethyl-benzoic acid (2R,3S,5R)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-5-(5-methyl-2,4-dioxo-3,4-dihydro-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Conditions

Conditions	Yield
With diphenyl(methyl)phosphine In 1,4-dioxane; water at 20℃; for 0.25h; Product distribution; Further Variations:; Catalysts; Reaction partners; Reagents; Solvents; reaction times;	96%

: bis(4-methoxyphenyl)phenylmethylium tetrafluoroborate

: 50-89-5
thymidine

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Conditions

Conditions	Yield
With 2,6-di-tert-butyl-4-methylpyridine In nitromethane at 20℃; for 17h; or pyridine, other solvents;	93%
With lithium carbonate; N-ethyl-N,N-diisopropylamine In tetrahydrofuran at 20℃; Heating;	74%

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 50-89-5
thymidine

A: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

B: 52417-09-1
3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine

Conditions

Conditions	Yield
With pyridine at 20℃; for 1.5h;	A 93% B n/a
With pyridine at 20℃; for 1.5h;	A 93% B n/a
With pyridine at 20℃; for 1.5h;	A 93% B n/a

...Expand

: 110-86-1
pyridine

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 50-89-5
thymidine

A: 847699-97-2
benzoic acid 5-(4-benzoylamino-5-methyl-2-oxo-2H-pyrimidin-1-yl)-2-[bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-tetrahydro-furan-3-yl ester

B: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Conditions

Conditions	Yield
at 20℃; for 1.5h;	A n/a B 93%

...Expand

: 40615-36-9
4,4'-dimethoxytrityl chloride

: 50-89-5, 3424-98-4, 4449-43-8, 4781-17-3, 16053-52-4, 36646-86-3, 39131-66-3, 68224-82-8, 128112-70-9, 131682-41-2, 137121-87-0
C10H14N2O5

A: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

B: 52417-09-1
3'-O-(4,4'-dimethoxytriphenylmethyl)-5'-O-fluorenylmethoxycarbonylthymidine

Conditions

Conditions	Yield
With pyridine at 20℃; for 0.5h;	A 93% B n/a
With pyridine at 20℃; for 1.5h;	A 93% B n/a

...Expand

: 342890-03-3
1-((2R,4S,5R)-5-[Bis-(4-methoxy-phenyl)-phenyl-methoxymethyl]-4-{[(E)-2-(3-hydroxy-naphthalen-2-yl)-vinyl]-diisopropyl-silanyloxy}-tetrahydro-furan-2-yl)-5-methyl-1H-pyrimidine-2,4-dione

A: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

B: 2,2-diisopropyl-2H-1-oxa-2-sila-anthracene

Conditions

Conditions	Yield
In methanol for 0.75h; Irradiation;	A n/a B 92%
In methanol for 0.75h; Irradiation;	A 92% B 91%

: 3868-27-7
triethylammonium 5'-O-dimethoxytritylthymidine 3'-H-phosphonate

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Conditions

Conditions	Yield
With pivaloyl chloride; ethylene glycol at 0℃; for 0.333333h; Hydrolysis;	91%

: 5'-O-(4,4'-dimethoxytrityl)-N3-(triphenylmethylsulfenyl)thymidine

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Conditions

Conditions	Yield
With tri-n-butyl-tin hydride In toluene at 115℃; for 0.0833333h;	82%

: 5'-dimethoxytrityl thymidine 3'-methylphosphinate

: 40615-39-2
5'-O-(4-4'-dimethoxytrityl)thymidine

Conditions

Conditions	Yield
With tetrabutyl ammonium fluoride In tetrahydrofuran; water for 3h; Ambient temperature;	73%

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Chemistry

Molecular Structure of 5'-O-dimethoxytrityl-deoxythymidine (CAS NO.40615-39-2):

IUPAC Name: 1-[(2R,4S,5R)-5-[[bis(4-methoxyphenyl)-phenylmethoxy]methyl]-4-hydroxyoxolan-2-yl]-5-methylpyrimidine-2,4-dione
Cas register number: 40615-39-2
Molecular formula: C₃₁H₃₂N₂O₆
Molecular Weight: 528.6
Density: 1.272 g/cm³
Index of Refraction: 1.602
Molar Refractivity: 146.9 cm³
Molar Volume: 427.8 cm³
Polarizability: 58.23×10^-24cm³
Surface Tension: 51.6 dyne/cm
Appearance: White Powder
Product Categories: Biochemistry;Nucleosides and their analogs;Nucleosides, Nucleotides & Related Reagents;Bases & Related Reagents;Carbohydrates & Derivatives;Nucleotides.

Safety Profile

Safety Statements about 5'-O-dimethoxytrityl-deoxythymidine (CAS NO.40615-39-2):
Hazard Codes:
Xi:
R36/37/38: Irritating to eyes, respiratory system and skin.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36: Wear suitable protective clothing.
F1: Sensitive to air and humidity.
F3: Hygroscopic.
F10: Keep under argon.
WGK Germany: 3
Hazard Note: Irritant

Specification

5'-O-dimethoxytrityl-deoxythymidine , its cas register number is 40615-39-2. It also can be called 5’-O-[bis(4-methoxyphenyl)phenylmethyl]-thymidin ; 5'-Dimethoxytrityl thymidine ; 5'-O-(4,4'-dimethoxytrityl)-2'-deoxythymidine ; 5'-O-[Bis(4-methoxyphenyl)benzyl]-2'-deoxythymidine ; 5'-O-(4,4'-dimethoxytrityl)thymidine ; 5-O-(4,4-dimethoxytrityl)thymidine ; 5'-O-dimethoxytrityl-deoxythymidine ; 5'-O-(dimethoxytrityl)-thymidine . Some useful informationabout Handling and Storage: Wash thoroughly after handling. Remove contaminated clothing and wash before reuse.Avoid contact with eyes, skin, and clothing. Avoid ingestion and inhalation.Keep refrigerated. (Store below 4°C/39°F.) Keep container closed when not in use. Store in a dry area.