Reference

Experimental therapy with 7 antimalarials in mice infected with pyronaridine-resistant Plasmodium berghei

Experimental therapy with 7 antimalarials in mice infected with pyronaridine-resistant Plasmodium berghei. Chen, Keyong; Lin, Baoying; Zhang, Jiaxun; Shao, Baoruo (Inst. Parasit. Dis., Chin. Acad. Med. Sci., Shanghai 200025, Peop. Rep. China). Zhongguo Yaoli Xuebao, 4(4), 269-73 (Chinese) 1983. CODEN: CYLPDN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) A pyronaridine [74847-35-1]-resistant strain of P. berghei in mice was cross-resistant to chloroquine [54-05-7], piperaquine [4085-31-8], quinine [130-95-0], and quinacrine [83-89-6] but sensitive to pyrimethamine [58-14-0] and sulfadoxine [2447-57-6]; the ED50 values of the latter 2 drugs were 52.2 and 0.67 mg/kg/day for 3 days, resp. Artemisin [481-05-0], with an ED50 of 1034 mg/kg/day for 3 days, was intermediate. 54-05-7 and 4085-31-8 are just another two chemicals used in this study. Combined treatment with pyrimethamine plus sulfadoxine had a potentiating effect. .

Antihistaminic effect of piperaquine

Antihistaminic effect of piperaquine. Fu, Dingyi; Cao, Lihua; Zhu, Lisha; Ma, Xiuxia (Dep. Pharmacol., Tangshan Min. Med. Coll., Tangshan 063013, Peop. Rep. China).Several substances like 4085-31-8 may be metioned in this study. Zhongguo Yaoli Xuebao, 4(4), 287-9 (Chinese) 1983. CODEN: CYLPDN. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Piperaquine (I) [4085-31-8] had antihistaminic action in tests in vivo and in vitro; this action appeared to be competitive with histamine. The pA2 of I in antagonizing histamine-induced contractions of the isolated guinea pig ileum was 5.4. .