CAS No.4097-22-7,Adenosine,2',3'-dideoxy- Suppliers

Detail of "4097-22-7"

CAS Number:

4097-22-7

Name:

Adenosine,2',3'-dideoxy-

Superlist Name:

Dideoxyadenosine

Molecular Structure:

Formula:

C₁₀H₁₃N₅O₂

Molecular Weight:

235.25

Synonyms:

2',3'-Dideoxyadenosine;NSC 98700;

EINECS:

223-853-2

Density:

1.76 g/cm³

Melting Point:

181-184 °C(lit.)

Boiling Point:

539.1 °C at 760 mmHg

Flash Point:

279.9 °C

Solubility:

Soluble in water

Appearance:

Off-white powder

Hazard Symbols:

Risk Codes:

34-36/37

Safety:

26-27-36/37/39-45 Details

particular:

particular

Reference

Contrasting effects of 2',3'-dideoxyadenosine on two steps in the replication of: Contrasting effects of 2',3'-dideoxyadenosine on two steps in the replication of .vphi.X174 DNA in Escherichia coli. McFadden, G.; Denhardt, D. T. (Dep. Biochem., McGill Univ., Montreal, Que., Can.). Virology, 76(2), 870-5 (English) 1977. CODEN: VIRLAX. DOCUMENT TYPE: Journal CA Section: 3 (Biochemical Interactions) The nucleoside analog 2',3'-dideoxyadenosine (I) [4097-22-7] inhibited the replication in vivo of both E. coli DNA and bacteriophage .vphi.X174 replicative form (RF) DNA. However, synthesis of the complement to the infecting single-stranded viral DNA to form the parental RF was not inhibited by the drug. The mol. basis for the differential effect of 2',3'-dideoxyadenosine on complementary strand synthesis and RF replication is not known, but possible reasons are discussed.

Effects of 2',3'-dideoxynucleosides on mammalian cells and viruses: Effects of 2',3'-dideoxynucleosides on mammalian cells and viruses. Waqar, M. Anwar; Evans, Mary Jo; Manly, Kenneth F.; Hughes, Robert G.; Huberman, Joel A. (Dep. Cell Tumor Biol., Roswell Park Mem. Inst., Buffalo, NY 14263, USA). J. Cell. Physiol., 121(2), 402-8 (English) 1984. CODEN: JCLLAX. ISSN: 0021-9541. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) The 2',3'-dideoxynucleosides (ddNs) 5'-triphosphates ddATP [24027-80-3], ddCTP [66004-77-1], and ddGTP [68726-28-3] were shown to affect cellular DNA polymerases a, b, and g in the same fashion as does ddTTP [611-60-9]. All 4 resp. ddNs in concns. up to 100 mM had negligible effects on the growth of NIH Swiss 3T3 cells. These negligible effects may be due to inefficient intracellular phosphorylation of each nucleoside to the triphosphate. It was detd. that, in several different cell lines, ddThd [3416-05-5] is phosphorylated only at a very slow rate to ddTTP, and in the one cell line tested (monkey CV-1 cells), ddAdo [4097-22-7] and ddGuo [85326-06-3] were also poorly phosporylated. Both ddAdo and ddGuo, and probably ddThd, are converted by CV-1 cells to addnl. unknown compds. which may have biol. activity. The 4 ddNs display effects of different magnitudes on certain virus infections. Although 30 mM ddThd inhibits herpes simplex I infection of CV-1 cells by 50%, 30 mM ddAdo has no effect. Infection of NIH Swiss 3T3 cells by 334C murine leukemia virus is inhibited 70-80% by ddAdo, ddCyd [7481-89-2] and ddThd at 50 mM, but inhibition by 50 mM ddGuo is 100%.

Detail of "4097-22-7"

Adenosine,2',3'-dideoxy-

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Reference