Detail of "4101-68-2"

Aldehydic agents for allosteric modification of hemoglobin: Aldehydic agents for allosteric modification of hemoglobin. Abraham, Donald J.; Boyiri, Telih; Safo, Martin; Danso-Danquah, Richmond (Center for Innovative Technology, USA). U.S. US 5599974 A 4 Feb 1997, 35 pp. (English). (United States of America). CODEN: USXXAM. CLASS: ICM: C07C051-42. NCL: 562463000. APPLICATION: US 1994-308805 19 Sep 1994. DOCUMENT TYPE: Patent CA Section: 63 (Pharmaceuticals) Section cross-reference(s): 25 Chem. compds. which interact inside the central water cavity of Hb and bridge between the two a subunits can be used to allosterically modify Hb towards tense and relaxed states. The functional groups employed are aldehydes and carboxylic acids, wherein the aldehydes form covalent bonds (Schiff base) with amino acid residues of Hb and the carboxylic acids form ionic bonds with amino acid residues of Hb. Particularly useful compds. 4101-68-2 and 166824-68-6 are just another two chemicals used in this study. within the practice of this invention bond to the N-terminal valine of one a subunit of Hb, and the lysine 99 and/or arginine 141 of the other a subunit. .

Preparation of novel 4-bromodecylthio (or 4-bromononylthio) uracils (or 6-methyluracils) as intermediates for synthesis of antibacterial azoniachalcone bromides: Preparation of novel 4-bromodecylthio (or 4-bromononylthio) uracils (or 6-methyluracils) as intermediates for synthesis of antibacterial azoniachalcone bromides. Wyrzykiewicz, Elzbieta; Nowakowska, Zdzislawa (Uniwersytet im. Adama Mickiewicza, Pol.). 4101-68-2 and 188242-24-2 are also occured in this study. Pol. PL 182779 B1 28 Feb 2002, 6 pp. (Polish). (Poland). CODEN: POXXA7. CLASS: ICM: C07D239-56. APPLICATION: PL 1995-312112 29 Dec 1995. DOCUMENT TYPE: Patent CA Section: 28 (Heterocyclic Compounds (More Than One Hetero Atom)) Section cross-reference(s): 1, 10 The title compds. I [R = H, Me; n = 9, 10] were prepd. by reacting thiouracil II [R = H, Me] with 1,9-dibromononane or with 1,10-dibromooctane in 0.1N methanolic soln. of NaOH at room temp. Thus, reacting 4-thiouracil with 1,9-dibromononane afforded 38% 4-(9-bromononyl)thiouracil. The compds. I were reacted with (E)-g-azachalcone III to provide the corresponding azoniachalcone bromides IV [R = H, Me; n = 9, 10] which showed antibacterial activity (biol. data given). Thus, reacting 4-(9-bromononyl)thiouracil with III afforded 41% IV [R = H; n = 9]. .