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Detail of "41136-22-5"

  • CAS Number:
  • 41136-22-5
  • Name:
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,8-oxo-7-[[2-(1H-tetrazol-1-yl)acetyl]amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-,sodium salt (1:1), (6R,7R)-

  • Superlist Name:
  • Ceftezole sodium
  • Molecular Structure:
  • Formula:
  • C13H12N8O4S3.Na
  • Molecular Weight:
  • 463.47
  • Synonyms:
  • 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylicacid,8-oxo-7-[(1H-tetrazol-1-ylacetyl)amino]-3-[(1,3,4-thiadiazol-2-ylthio)methyl]-,monosodium salt, (6R-trans)- (9CI);Celoslin;Sodium7-[(1H-tetrazol-4-yl)acetyl]-3-(1,3,4-thiadiazol-5-ylthio)cephalosporanate;

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CAS No.41136-22-5 Ceftezole sodiumCompetitive Product

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Ceftezole acid

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CAS No.41136-22-5 Ceftezole sodium

  Package:The cardboar...

Structural formula: C13H12N8O4S3 Uses: The head spore is that the masculine gender bacterium and feminine gender bacterium composing the head spore centre body for azole sodium , dismissing Mrs. an orchid the head the spore for azole sodium to many have the antibiosis broad eff

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ceftezole sodium

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97% Min

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Sell Ceftezole sodium raw material CAS No.:41136-22-5 status: in stock

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Description: For injection

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Reference

Ceftezole, a new cephalosporin C derivative
Ceftezole, a new cephalosporin C derivative. II. Distribution and excretion in parenteral administration.Several substances are used for example 27164-46-1 and 50-59-9 which are their cas registry numbers. Harada, Yusuke; Matsubara, Shuzo; Kakimoto, Morio; Noto, Takao; Nehashi, Toshiyuki; Kimura, Takao; Suzuki, Seikichi; Ogawa, Haruki; Koyama, Kenjiro (Res. Lab., Chugai Pharm. Co., Ltd., Tokyo, Japan). J. Antibiot., 29(10), 1071-82 (English) 1976. CODEN: JANTAJ. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In animal studies ceftezole Na (I) [41136-22-5] concns. in the blood decreased more rapidly than did concns. of cefazolin Na [27164-46-1]. Furthermore, the excretion of I was faster than that of cefazolin. When ceftezole was administered intramuscularly to human volunteers in a single dose of 500 mg, it disappeared from the blood 6 hrs after administration. I was excreted rapidly by humans, 79.5% in the 1st 3 hrs. The initial concn. of I in the urine was high. I was excreted in human urine in the active form undergoing minimal metab. Thus, ceftezole could be especially effective in the treatment of clin. urinary infections. Biliary excretion of ceftezole in rats and dogs was somewhat lower than that of cefazolin but much higher than those of cephaloridine [50-59-9] and cephalothin Na [58-71-9]. The tissue distribution of I was similar to that of cefazolin but I was distributed more rapidly and the rate of decrease in the tissue was also faster. Peak levels of I in lymph and the exudate of inflammatory pouches were slightly higher than those of cefazolin. These results also imply good distribution of ceftezole in various tissues. Repeated administration of ceftezole to rabbits did not affect the pattern of the blood level and urinary excretion. Therefore, it is probable that repeated administration of ceftezole to humans is unlikely to cause toxic manifestation related to accumulation of the antibiotic in various tissues. .
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