Reference

Synthesis and platelet aggregation inhibitory activity of 4,5-bis(substituted)-1,2,3-thiadiazoles

Synthesis and platelet aggregation inhibitory activity of 4,5-bis(substituted)-1,2,3-thiadiazoles. Thomas, Edward W.Several substances are used for example 4114-31-2 which is its cas registry number.; Nishizawa, Edward E.; Zimmermann, David C.; Williams, Davey J. (Upjohn Co., Kalamazoo, MI 49001, USA). J.Chemical with cas number 4114-31-2 also plays role. Med. Chem., 28(4), 442-6 (English) 1985. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacology) Section cross-reference(s): 28 The title compds. I (R and R1 = H, Me, (un)substituted Ph; RR1 = (CH2)10] prepd. by condensation of the appropriate ketone with either Et carbazate [4114-31-2] or p-tolylsulfonyl hydrazide [1576-35-8] to the resp. hydrazone followed by treatment of this with SO2Cl, were screened as inhibitors of collagen-induced aggregation of human platelet-rich plasma. 4,5-Bis(p-methoxyphenyl)-1,2,3-thiadiazole (I; R and R1 = 4-MeOC6H4) [94843-16-0] was among the most active compds. Structure-activity relations are discussed. ..

Chemical modification of natural rubber - a new silane coupling agent

Chemical modification of natural rubber - a new silane coupling agent. Dawes, K.; Rowley, R. J. (Malay. Rubber Prod. Res. Assoc., Brickendonbury/Hertford, Engl.). Plast. Rubber: Mater. Appl., 3(1), 23-6 (English) 1978. CODEN: PRMAD9. ISSN: 0307-9414. DOCUMENT TYPE: Journal CA Section: 38 (Elastomers, Including Natural Rubber) Silica-filled natural rubber was modified with 1.7 phr ethyl N-(3-triethoxysilylpropyl)carbamoylazoformate (I) [64185-88-2] coupling agent, prepd. by oxidn. of the reaction product of (3-isocyanatopropyl)triethoxysilane [24801-88-5] with ethyl carbazate [4114-31-2], to give a product having a Mooney scorch 7.0 min, flexural strength 3.49 MPa, 100% modulus 5.76 MPa, tensile strength 17.0 MPa, elongation at break 195%, Dunlop resilience 91.7%, 24 h 70% compression set 36%, Goodrich heat buildup 9.5%, and Akron abrasion 25, compared with 9.5, 1.67, 2.14, 28.9, 635, 76.6, 54, 27, and 133, resp., for rubber not contg. I, and 2.7, 2.08, 2.75, 19.1, 425, 64.2, 52, 44, and 81, resp., for the rubber contg. 1.7 phr A 189 instead of I.