CAS No.41175-50-2,8-HYDROXYJULOLIDINE Suppliers,MSDS download

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Basic Information

Molecular Structure:
CAS No.:	41175-50-2
Name:	8-HYDROXYJULOLIDINE
Article Data:	31

Formula:	C₁₂H₁₅NO
Molecular Weight:	189.257
Synonyms:	2,3,6,7-Tetrahydro-1H,5H-pyrido[3,2,1-ij]quinolin-8-ol;
EINECS:	255-247-9
Density:	1.23 g/cm³
Melting Point:	132-134 °C(lit.)
Boiling Point:	374.427 °C at 760 mmHg
Flash Point:	213.494 °C
Solubility:	Soluble in water (partly), ethanol, chloroform, methanol, and acetone.
Appearance:	pink to beige or brown fine crystalline powder
Hazard Symbols:	Xi
Risk Codes:	36/37/38
Safety:	22-24/25-37/39-26-36
PSA:	23.47000
LogP:	2.15600

Synthetic route

: 109-70-6
1,3-chlorobromopropane

: 591-27-5
m-Hydroxyaniline

: 41175-50-2
8-hydroxyjulolidine

Conditions

Conditions	Yield
With sodium carbonate In N,N-dimethyl-formamide at 75℃; for 9h;	84.6%
With sodium carbonate In N,N-dimethyl-formamide at 80℃; for 15h; Inert atmosphere;	69%
With sodium hydrogencarbonate In N,N-dimethyl-formamide at 70℃;	68%

: 536-90-3
m-Anisidine

: 109-70-6
1,3-chlorobromopropane

: 41175-50-2
8-hydroxyjulolidine

Conditions

Conditions	Yield
Stage #1: m-Anisidine; 1.3-chlorobromopropane at 20 - 140℃; for 45.5h; Inert atmosphere; Reflux; Stage #2: With hydrogen iodide for 6h; Reflux;	70.1%
Stage #1: m-Anisidine; 1.3-chlorobromopropane Heating; Stage #2: With hydrogen bromide for 3.5h; Heating;	52%
at 95 - 180℃;	39%
Stage #1: m-Anisidine; 1.3-chlorobromopropane With sodium carbonate at 100℃; for 11h; Stage #2: With hydrogenchloride; hydrogen iodide for 60h; Reflux;
Stage #1: m-Anisidine; 1.3-chlorobromopropane With ammonium acetate at 140℃; for 15h; Inert atmosphere; Stage #2: With hydrogenchloride; hydrogen iodide In water for 24h; Reflux; Inert atmosphere;	1.5 g

: 63468-83-7
8-methoxy-1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinoline

: 41175-50-2
8-hydroxyjulolidine

Conditions

Conditions	Yield
With hydrogenchloride; hydrogen iodide In water for 60h; Heating;	67%
With hydrogenchloride; hydrogen iodide In water Reflux;	67%
With hydrogen iodide In water Inert atmosphere; Reflux;	1.32 g

: 536-90-3
m-Anisidine

nitrosylsulfuric acid: nitrosylsulfuric acid

: 41175-50-2
8-hydroxyjulolidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: 64 percent / sodium carbonate, 4-A molecular sieves / a) from 70 deg C to 100 deg C, 3 h, b) reflux, 11 h 2: 67 percent / 47percent HI, conc. HCl / H2O / 60 h / Heating View Scheme

: 536-90-3
m-Anisidine

: 41175-50-2
8-hydroxyjulolidine

Conditions

Conditions	Yield
Multi-step reaction with 2 steps 1: Heating 2: hydrogen iodide / Heating View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate / 14 h / 70 - 100 °C 2: hydrogenchloride; hydrogen iodide / water / Reflux View Scheme
Multi-step reaction with 2 steps 1: sodium carbonate / 19 h / 70 - 150 °C 2: pyridine hydrochloride / 2 h / 200 °C View Scheme
Multi-step reaction with 2 steps 1.1: sodium hydrogencarbonate / 2 h / 95 - 150 °C / Industrial scale 2.1: hydrogen iodide / 16 h / 110 °C / Industrial scale 2.2: pH 7 - 8 / Industrial scale View Scheme
Multi-step reaction with 2 steps 1.1: sodium carbonate / 3 h / 65 - 100 °C / Industrial scale 2.1: hydrogen iodide / 16 h / 110 °C / Industrial scale 2.2: pH 7 - 8 / Industrial scale View Scheme

: 41175-50-2
8-hydroxyjulolidine

: 4-formylbenzene-1,3-disulfonic acid dipotassium salt

: 1629670-53-6
C19H19NO7S2

Conditions

Conditions	Yield
In methanesulfonic acid at 150℃; for 0.25h; Sealed tube;	100%

: 41175-50-2
8-hydroxyjulolidine

: 1175621-48-3
5-(tert-butoxycarbonylamino)pent-2-ynoic acid

: 1386264-09-0
8-(2,3,6,7-tetrahydro-1H,5H-benzo[ij]quinolizine) 5-(tert-butoxycarbonylamino)pent-2-ynoate

Conditions

Conditions	Yield
With dmap; diisopropyl-carbodiimide In dichloromethane at 0℃; for 2h; Inert atmosphere; Sealed tube;	98%

: 41175-50-2
8-hydroxyjulolidine

: 99017-63-7
methyl 5-<(benzyloxycarbonyl)amino>-3-oxopentanoate

: 8-(2-aminoethyl)-2,3,4,5-tetrahydro-1H,4H-11-oxa-3a-aza-benzo-[de]anthracen-10-one hydrochloride

Conditions

Conditions	Yield
Stage #1: 8-hydroxyjulolidine; methyl 5-<(benzyloxycarbonyl)amino>-3-oxopentanoate With triisopropoxytitanium(IV) chloride In hexane Stage #2: With hydrogenchloride at 95℃; for 9h;	98%
Stage #1: 8-hydroxyjulolidine; methyl 5-<(benzyloxycarbonyl)amino>-3-oxopentanoate With triisopropoxytitanium(IV) chloride In hexane; toluene for 12h; Reflux; Stage #2: With hydrogenchloride In water at 95℃; for 9h;	4.3 g

: 41175-50-2
8-hydroxyjulolidine

: 68-12-2, 33513-42-7
N,N-dimethyl-formamide

: 63149-33-7
9-formyl-8-hydroxyjulolidine

Conditions

Conditions	Yield
With trichlorophosphate at 0 - 80℃; for 1.25h; Inert atmosphere;	97.6%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 4℃; for 0.25h; Stage #2: 8-hydroxyjulolidine at 20 - 100℃; for 1h;	94%
Stage #1: N,N-dimethyl-formamide With trichlorophosphate at 4℃; for 0.25h; Stage #2: 8-hydroxyjulolidine In water at 4 - 100℃; for 2.5h;	94%

: 41175-50-2
8-hydroxyjulolidine

: 182359-86-0
4-cyano-1-methyl-3-methylthio-1H-pyrrole-2,5-dione

: 2-Methyl-7,8,10,11-tetrahydro-6H,9H-5-oxa-2,8a-diaza-benzo[fg]cyclopenta[a]anthracene-1,3,4-trione

Conditions

Conditions	Yield
In acetic acid Heating;	96%

Total:98 Page 1 of 3 1 2 3 Next>>

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Chemistry

Following is the structure of 1H,5H-Benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro- (CAS NO.41175-50-2):

Empirical Formula: C₁₂H₁₅NO
Molecular Weight: 189.2536 g/mol
EINECS: 255-247-9
Index of Refraction: 1.645
Molar Refractivity: 55.84 cm³
Molar Volume: 153.8 cm³
Density: 1.22 g/cm³
Flash Point: 213.5 °C
Melting point: 132-134 °C(lit.)
Surface Tension: 57 dyne/cm
Enthalpy of Vaporization: 64.62 kJ/mol
Boiling Point: 374.4 °C at 760 mmHg
Vapour Pressure: 3.88E-06 mmHg at 25 °C
Appearance: pink to beige or brown fine crystalline powder
Canonical SMILES: C1CC2=C3C(=C(C=C2)O)CCCN3C1
InChI: InChI=1S/C12H15NO/c14-11-6-5-9-3-1-7-13-8-2-4-10(11)12(9)13/h5-6,14H,1-4,7-8H2
InChIKey: FOFUWJNBAQJABO-UHFFFAOYSA-N

Toxicity Data With Reference

H,5H-Benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro- (CAS NO.41175-50-2) hasn't been listed as a carcinogen by ACGIH, IARC, NTP, or CA Prop 65.

Safety Profile

Hazard Codes: Irritant Xi
Risk Statements: 36/37/38
R36/37/38:Irritating to eyes, respiratory system and skin.
Safety Statements: 22-24/25-37/39-26-36
S22:Do not breathe dust.
S24/25:Avoid contact with skin and eyes.
S37/39:Wear suitable gloves and eye/face protection.
S26: In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36:Wear suitable protective clothing.
WGK Germany: 3
F: 10

Specification

1H,5H-Benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro- , its cas register number is 41175-50-2. It also can be called 2,3,6,7-Tetrahydro-1H,5H-benzo(ij)quinolizin-8-ol ; and 8-Hydroxyjulolidine .
1H,5H-Benzo[ij]quinolizin-8-ol,2,3,6,7-tetrahydro- (CAS NO.41175-50-2) could be stable under normal temperatures and pressures. It should avoid the condition like incompatible materials. It is not compatible with strong oxidizing agents. And also prevent it to broken down into hazardous decomposition products: irritating and toxic fumes and gases. However, its hazardous polymerization has not been reported.