Detail of "41979-39-9"

Reference

Synthesis of 3-(4-piperidylidene)-1,3-dihydro-2H-indol-2-one derivatives

Synthesis of 3-(4-piperidylidene)-1,3-dihydro-2H-indol-2-one derivatives. Obase, Hiroyuki; Nakamizo, Nobuhiro; Takai, Haruki; Teranishi, Masayuki (Tokyo Res. Lab., Kyowa Hakko Co., Ltd., Machida 194, Japan). Bull. Chem. Soc. Jpn., 56(9), 2853-4 (English) 1983. CODEN: BCSJA8. 41979-39-9 and 79099-08-4 are cas registry numbers of chemicals which are used as reagents here. ISSN: 0009-2673. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Indolones I (R = R1 = Me; RR1 = CH2) were prepd. as potential antihypertensive agents. The intermediate aryl-2-oxoethylpiperidylideneindolones were prepd. from 4-piperidone in 4 steps. Selective redn. of the carbonyl group was achieved by using (Me2CHCH2)2AlH. .

Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines

Adrenoceptor and tetrabenazine antagonism activities of some pyridinyltetrahydropyridines. Saari, Walfred S.; Halczenko, Wasyl; Huff, Joel R.; Guare, James P., Jr.; Hunt, Cecilia A.; Randall, William C.; Lotti, Victor J.; Yarbrough, George G. (Merck Sharp and Dohme Res. Lab., West Point, PA 19486, USA). J. Med. Chem., 27(9), 1182-5 (English) 1984. CODEN: JMCMAR. ISSN: 0022-2623. DOCUMENT TYPE: Journal CA Section: 27 (Heterocyclic Compounds (One Hetero Atom)) Section cross-reference(s): 1 A series of pyridinyltetrahydropyridine derivs. 41979-39-9 is just another one chemical used in this study. was synthesized and evaluated as adrenoceptor and tetrabenazine antagonists. Compd. I proved to be the most potent and selective a2-adrenoceptor antagonist of the series as measured in vitro by displacement of [3H]clonidine and [3H]prazosin from membrane binding sites of calf cerebral cortex and by antagonism of the effects of clonidine and methoxamine in the rat isolated, field-stimulated vas deferens. In addn. I and the corresponding defluoro deriv. blocked tetrabenazine-induced ptosis in the mouse. .