Reference

Effects of 2-methyl-2-[4-(4'-chlorobenzoyl)phenoxy]propionic acid (LF 153) on respiration and oxidative phosphorylation of rat liver mitochondria

Effects of 2-methyl-2-[4-(4'-chlorobenzoyl)phenoxy]propionic acid (LF 153) on respiration and oxidative phosphorylation of rat liver mitochondria. De Grimal, P.; Goudonnet, H.; Truchot, R. (Lab. Biochim. Pharm., Fac. Sci. Pharm. Biol., Dijon, Fr.). C. R. Seances Soc. Biol. Ses Fil., 171(1), 93-9 (French) 1977. CODEN: CRSBAW. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) In isolated rat hepatic mitochondria, LF 153 (I) [42017-89-0] behaved as a respiration inhibitor and phosphorylation uncoupler; the latter effect being very marked.

Gas-liquid chromatographic determination of procetofenic acid in human plasma and urine

Gas-liquid chromatographic determination of procetofenic acid in human plasma and urine. Desager, J. P. (Lab. Pharmacother., Univ. Catholique Louvain, Brussels, Belg.). J. Chromatogr., 145(1), 160-4 (English) 1978. CODEN: JOCRAM. DOCUMENT TYPE: Journal CA Section: 1 (Pharmacodynamics) A method is described for the detn. of procetofenic acid (I) [42017-89-0] in blood and urine. I was extd. from plasma or hydrolyzed urine with Et2O. The compd. was dissolved in n-hexane and injected on to a gas chromatog. column packed with 4% SE-30 on Gas-chrom Q, 80-100 mesh with N as the carrier gas at 230°. An electron-capture detector was used. A calibration curve was made for I concns. in plasma and urine between 100 ng and 6 mg. It was possible to detect 10 ng I/mL in biol. fluids. The free fraction of I in urine was estd. to be 1-2%. The clearance of I from blood plasma and I urinary excretion were detd. in a normal volunteer receiving lipanthyl (procetophen) [49562-28-9].